Endometriosis: new genetic approaches and therapy

Barlow DH, David H. Barlow, Kennedy S, Stephen Kennedy
Annual review of medicine · 2005 · vol. 56(1) , pp. 345–356 · doi:10.1146/annurev.med.55.091902.103805 · PMID:15660516 · W2165257778
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This review discusses current genetic approaches like expression profiling and linkage studies used to understand endometriosis pathophysiology and identify potential new therapeutic targets.

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Abstract

Endometriosis is a relatively common condition in women of reproductive age and is associated with considerable morbidity. Despite an extensive literature describing its multiple clinical manifestations, their management, and many aspects of the biology of endometriotic lesions, the pathophysiological mechanisms involved remain poorly understood. A genetic component in endometriosis is now recognized, and several groups have taken up the challenge of using genetic techniques to identify the aberrant molecular and cellular mechanisms in endometriosis with the intention of providing much-needed insights that might, in turn, lead to new therapies. The techniques that have been applied include expression profiling, tumor genetic studies, functional candidate gene studies, and linkage studies that can adopt a hypothesis-free approach. This review describes the current status of these studies and explores the prospects for new therapies.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Techniques Genetic Techniques Gonadotropin-Releasing Hormone Anastrozole Anastrozole Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Drug Therapy, Combination Drug Therapy, Combination Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (59)

Cited by (50)

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