Expression of nerve growth factor (NGF) in endometrium as a potential biomarker for endometriosis - Single tertiary care centre study

Maria Szubert; Rogut M; Magdalena Rogut; Ziętara M; Magdalena Ziętara; Tomasz Wierzbowski; Wierzbowski T; Jacek Wilczyński; Jacek R. Wilczyński; Małgorzata Czyż

doi:10.1016/j.jogoh.2020.101895

Expression of nerve growth factor (NGF) in endometrium as a potential biomarker for endometriosis - Single tertiary care centre study

Maria Szubert, Rogut M, Magdalena Rogut, Ziętara M, Magdalena Ziętara, Tomasz Wierzbowski, Wierzbowski T, Jacek Wilczyński, Jacek R. Wilczyński, Małgorzata Czyż

Journal of gynecology obstetrics and human reproduction · 2020 · vol. 50(3) , pp. 101895 · doi:10.1016/j.jogoh.2020.101895 · PMID:32827836 · W3076503284

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This study investigated the expression of nerve growth factor (NGF) in the endometrium to determine its potential as a biomarker for endometriosis.

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Abstract

OBJECTIVE: to identify novel biomarkers for peritoneal endometriosis in eutopic endometrium thus giving an oportunity for non-invasive diagnosis. DESIGN: A cross-sectional single-center study SETTING: tertiary care hospital PATIENTS: 49 patients subjected to laparoscopy because of suspected endometriosis, 33 patients out of the group qualified to the study had sufficient endometrial tissue taken and were in their follicular phase of menstrual cycle. INTERVENTIONS: biopsy sampling of eutopic endometrial tissue during diagnostic or diagnostic and terapeutic laparoscopy, questionaires, MAIN OUTCOME MEASURE(S): qRT-PCR to evaluate the mRNA expression of selected candidate marker genes in endometrium: ARO1 (aromatase), CXCL8 (interleukin 8), NGF (nerve growth factor), VEGF-A (vascular endothelial growth factor A), PDGF-A (platelet-derived growth factor A). RESULTS: mRNA expression of ARO1, CXCL8, VEGF-A and PDGF-A did not differ significantly between women with and without endometriosis. NGF mRNA expression was decreased in women with endometriosis. CONCLUSIONS: Observed preliminary results suggest a possible role of NGF in early diagnosis of peritoneal endometriosis. The role of NGF changes in eutopic endometrium of patients with peritoneal endometriosis needs further evaluation.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Endometrium Nerve Growth Factor RNA, Messenger Adult Adult Aromatase Aromatase Aromatase Biomarkers Biomarkers Case-Control Studies Case-Control Studies Cross-Sectional Studies Cross-Sectional Studies Endometriosis Endometriosis Endometrium Endometrium

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References (44)

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