Characterization of leukocyte subpopulations in the peritoneal fluid of women with endometriosis

Joseph A. Hill, J A Hill, Hill JA, H M Faris, Faris HM, Heidi M.P. Faris, Schiff I, Isaac Schiff, I Schiff, D J Anderson, Deborah J. Anderson, Anderson DJ
Fertility and sterility · 1988 · vol. 50(2) , pp. 216–222 · doi:10.1016/s0015-0282(16)60062-6 · PMID:3294043 · W2395123280
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Peritoneal fluid leukocyte subpopulations, particularly macrophages, helper T cells, and NK cells, were elevated in women with endometriosis and unexplained infertility compared to fertile controls.

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Abstract

Monoclonal antibodies identifying leukocytes subpopulations were applied to smears of laparoscopically collected peritoneal fluid leukocytes and parallel samples of peripheral blood leukocytes from women with endometriosis (n = 33), those with unexplained infertility (n = 9), and fertile controls (n = 8). Peripheral blood leukocyte profiles in all groups were indistinguishable from reported normal values. Peritoneal fluid leukocyte profiles were observed to be different between groups. The most significant elevations in total leukocytes, macrophages, helper T lymphocytes and natural-killer cells were observed in women with stage I and II endometriosis. Significantly elevated levels of total leukocytes, macrophages, and T lymphocytes were also observed in peritoneal fluid from women with unexplained infertility. The results from this study indicate that the peritoneal environment is immunologically dynamic and suggest that cellular immune mechanisms may contribute to reproductive failure in women with endometriosis and unexplained infertility.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Leukocytes Antibodies, Monoclonal Antibodies, Monoclonal Ascitic Fluid Ascitic Fluid Cell Survival Cell Survival Endometriosis Endometriosis Endometriosis Female Female Humans Humans Immunoenzyme Techniques Immunoenzyme Techniques Infertility, Female Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (50)

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