Effects of dienogest on surgically induced endometriosis in rats after repeated oral administration

Fischer OM, Oliver M. Fischer, O M Fischer, U. Kaufmann-Reiche, Kaufmann-Reiche U, Moeller C, C. Moeller, Chaim Moeller, U. Fuhrmann, Fuhrmann U
Gynecologic and obstetric investigation · 2011 · vol. 72(3) , pp. 145–151 · doi:10.1159/000331642 · PMID:21985956 · W2037277061
Lab / animal OA: closed CC0 ⤵ 38 in-corpus citations
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Dienogest 0.3 mg/kg/day administered orally for 28 days significantly reduced surgically induced endometriosis lesion size in rats without estrogenic effects, comparable to danazol 100 mg/kg/day.

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Abstract

BACKGROUND: Dienogest demonstrates efficacy for lesion reduction and pain relief in clinical trials of endometriosis. The current study investigated an intraperitoneal animal model of endometriosis to further characterize the effects of dienogest. METHODS: Endometrial-like lesions were induced in rats by autotransplantation of uterine tissue into the peritoneal cavity. Dienogest 0.3 or 1.0 mg/kg/day, danazol 100 mg/kg/day, or vehicle control were administered orally for 28 days. Changes in endometrial-like lesion size during treatment were assessed at laparotomy. Uterine horn weight was also measured as an index of the estrogenic effects of treatment. RESULTS: Dienogest 0.3 mg/kg/day significantly reduced the total endometrial lesion area, with an effect equivalent to danazol 100 mg/kg/day. Unlike dienogest 1.0 mg/kg/day, dienogest 0.3 mg/kg/day had no effect on uterine horn weight, indicating an absence of estrogenic effects for this dose in rodents. CONCLUSION: Dienogest 0.3 mg/kg/day for 28 days demonstrated potent inhibitory activity on the growth of endometrial tissue in this model, providing supportive evidence for the efficacy of dienogest in lesion reduction.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Disease Models, Animal Endometriosis Hormone Antagonists Nandrolone Animals Animals Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Hormone Antagonists

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (42)

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