Effect of dexamethasone versus propranolol on surgically induced endometriosis in an experimental animal model

NaglaaM.S Emsalem, Samia Fahmy, DoaaM Effat, AhmedM Abdellah
In: The Scientific Journal of Al-Azhar Medical Faculty, Girls · 2020 · vol. 4(2) , pp. 159 · doi:10.4103/sjamf.sjamf_17_20 · W3039681371
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study found that both propranolol and dexamethasone significantly reduced endometriotic implant size in rats by restricting angiogenesis, as indicated by reduced VEGF levels.

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The study investigated the comparative efficacy of dexamethasone and propranolol in managing surgically induced endometriosis within an experimental animal model. Researchers utilized a rodent model to evaluate how these distinct pharmacological agents influenced the progression or severity of the induced lesions compared to control conditions. The findings highlighted specific differences in therapeutic outcomes between the anti-inflammatory corticosteroid and the beta-blocker, providing insight into their respective mechanisms for treating this condition in vivo. This paper is centrally about endometriosis — specifically examining pharmacological interventions in a surgically induced animal model.

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Abstract

Background Endometriosis is a disease of adolescents and reproductive-aged women characterized by the presence of endometrial tissue outside the uterine cavity and commonly associated with chronic pelvic pain and infertility. The mechanisms responsible for its pathogenesis and progression remain poorly understood. It is well established that endometriosis grows and regresses in estrogen-dependent fashion, and the diseases can be effectively cured by definitive surgery. However, prolonged medical therapy may be needed in most of the cases. Objective The objective of this study is to evaluate the effects of dexamethasone versus propranolol in rats with surgically induced endometriosis on vascular endothelial growth factor (VEGF) as a marker in the implanted tissue. Materials and methods The study was conducted in the Animal Research Unit of Medical Research Center of Ain Shams University. All procedures were performed from May 2018 to September 2018, in compliance with the international guidelines for care and use of experimental animals, on 100 female Wistar albino rats 90 days old, which were randomly divided into three groups: first group was treated with dexamethasone (n=40), and second group was treated with propranolol (n=40), and third group was a control group (n=20). They were used to create a model for the experimental induction of endometriosis and evaluation of therapeutic effect of dexamethasone versus propranolol. Results In the first group after treatment with dexamethasone, there was a highly statistically significant decrease in size of implant tissue (P Conclusion Both propranolol and dexamethasone efficiently reduced the size of endometriotic implant in conditions of surgical-induced endometriosis in rats. This is through restriction of angiogenesis through VEGF, which was utilized as a marker. So, it can be deemed that the drugs could be promoted in conditions of endometriosis in humans, but they require more research studies for assessment in humans.
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Condition tags

endometriosischronic_pelvic_paininfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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