Histological Evaluation of the Induced Endometriosis in Rats, after Treatment with Dexamethasone

Ana Paula Castor Batista, Ana Paula Maria da Conceição, Eleonora de Figueiredo Moraes, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley Teixeira
In: International Journal of Morphology · 2006 · vol. 24(4) · doi:10.4067/s0717-95022006000500008 · W2052406162
article OA: diamond CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study evaluated the effect of dexamethasone treatment duration on induced endometriosis in rats, finding that 15 days of treatment, but not 10 days, reversed inflammation and stimulated gland proliferation in implants.

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Abstract

The present research had the purpose to analyze morphologically the sites of endometrial implants on the external area of the musculature of the anterior abdominal wall of female rats, treated with dexamethasone. For so, these 15 albino female rats were used (Rattus norvegicus albinus), of the lineage Wistar with 90 days of age, that were submitted to the induction of the endometriosis, and divided in the following groups: Group I -induced female rats to endometriosis and evaluated after 21 days (control); Group IIinduced female rats to endometriosis and after 21 days, treated with dexamethasone for 10 days; Group III -induced female rats to endometriosis, and after 21 days, treated with dexamethasone for 15 days. The dexamethasone was administered in the dosage of 0,8 mg/ day/animal. Our results showed that the chronic inflammatory process in the endometriosis doesn't decrease after treatment with dexamethasone for 10 days, while the treatment with dexamethasone for 15 days reverted the chronic inflammatory process in the endometriosis, besides stimulating the proliferation of glands in endometrial implants.

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endometriosis

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