Is montelukast effective in regression of endometrial implants in an experimentally induced endometriosis model in rats?

Şadıman Kıykaç Altınbaş, Sadiman Kiykac Altinbas, Omer Lutfi Tapisiz, Ömer Lütfi Tapısız, Cavkaytar S, Sabri Cavkaytar, Simsek G, Gülçin Şımşek, Gulcin Simsek, Oguztuzun S, Serpil Oguztuzun, Serpil Oğuztüzün, Goktolga U, Umit Goktolga, Ümit Göktolga
European journal of obstetrics, gynecology, and reproductive biology · 2014 · vol. 184 , pp. 7–12 · doi:10.1016/j.ejogrb.2014.10.026 · PMID:25462212 · W2014770933
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This study investigated whether montelukast could regress experimentally induced endometriosis implants in a rat model.

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Abstract

ObjectiveMontelukast, a selective antagonist of Type 1 cysteinyl leukotriene receptors (CysLT1Rs), antagonizes the proinflammatory and proasthmatic activities of CysLT1Rs. We investigated the effect of montelukast on a surgically induced endometriosis rat model.Study designThirty-two sexually mature, cycling, female Wistar-Albino rats, in which endometriotic implants were surgically induced, were randomly divided into three groups. Group I [Montelukast (M), 10 rats)] was given 1.6 mg/kg/day of oral montelukast sodium. Group II [Leuprolide acetate (L), 11 rats] was given 1 mg/kg single dose of s.c.leuprolide acetate. Group III [Control (C), 11 rats] received saline solution through an orogastric tube and served as controls. After a 3-weeks medication, the rats were sacrificed to investigate the endometriotic implants for size and morphological and histological characteristics, including immunoreactivity of MMP-2 and VEGF.ResultsThe mean area of implants decreased from 48.2 ± 24.7 to 29.3 ± 15.8mm(2) in Group I (M) (P = 0.008) and from 62 ± 32.1 to 39.9 ± 18.1mm(2) in Group II (L) (P=0.003). In Group III (C), the mean area increased from 41.1 ± 31.1 to 60.4 ± 37.1mm(2) (P = 0.025). Histopathological analysis showed statistically significant lower scores in rats treated with montelukast compared to leuprolide and controls. MMP H scores were not different between the groups in both epithelial and stromal MMP-2 immunostaining. VEGF H scores were statistically lower in Group 1 (M) in epithelial VEGF immunostaining when compared to Group II (L) and Group III (C) (P=0.006).Conclusion(s)Montelukast may effectively cause a significant decrease in the area of endometriotic implants.

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Condition tags

endometriosis

MeSH descriptors

Acetates Anti-Inflammatory Agents Endometriosis Endometrium Quinolines Acetates Acetates Animals Anti-Inflammatory Agents Anti-Inflammatory Agents Cyclopropanes Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Leuprolide

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