The effect of antiangiogenic agent aflibercept on surgically induced endometriosis in a rat model

Çağlayan Ateş, Berna Dilbaz, Seval Yılmaz Ergani, Fuad Atabay
In: Cirugía y Cirujanos (English Edition) · 2024 · vol. 92(1) · doi:10.24875/cirue.m23000605 · W4396905710
article OA: diamond CC0 ⤵ 1 in-corpus citation
📄 Open PDF View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Aflibercept significantly reduced endometriosis lesion volume, improved adhesions, and decreased VEGF-H and CD31 expression compared to leuprolide acetate in a rat model.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Objective:The aim of the study is to show for the first time how aflibercept affects endometriosis lesions.Material and methods: Surgically induced endometriosis in Wistar albino female rats.Rats with endometriosis were randomly divided into three groups: control (Co), aflibercept (Af), and leuprolide acetate (Le).Then, Af, aflibercept, and Le received leuprolide acetate.The control group was not treated.The weights and changes in intra-abdominal adhesions of the rats before and after treatment were recorded according to the Blauer adhesion score.Blood extracted for sacrifice was analyzed.Endometriotic lesions were evaluated for size, volume, histology, and immunohistochemistry (vascular endothelial growth factor [VEGF] and CD31).Significance level was accepted as p < 0.05.Results: Aflibercept significantly reduced endometrial implant volume (p = 0.002).The explant epithelial histological score showed a significant difference between aflibercept and leuprolide acetate (p = 0.006) and between aflibercept and control groups (p = 0.002).Aflibercept decreased VEGF-H and CD31 expression (p = 0.001) more than leuprolide acetate.Aflibercept improved adhesions (p = 0.006).Conclusion: Aflibercept is more successful than leuprolide acetate in the treatment of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK