Progestational activity of danazol in the human female subject
Non-randomised trial
OA: closed
CC0
⤵ 31 in-corpus citations
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This paper examines the progestational activity of Danazol in human female subjects.
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Abstract
A progestational action of Danazol has not been reported in the human subject. Danazol administration for 1 month suppressed serum FSH and estradiol values, and the midcycle LH surge; ovulation promptly resumed after treatment. Administration to patients with polycystic ovarian disease resulted in increased LH values, elevated basal temperature, secretory findings in the endometrial biopsy, and menses. Ovarian biopsy did not document corpus luteum formation, and plasma progesterone did not rise. Administration of Danazol to an ovariectomized patients pretreated with estrogen resulted in an atypical endometrial secretory change. Clinical responses to Danazol may in part be explained by a progestational-like effect of the drug.
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References (9)
- A competitive radioligand assay for danazol (17 alpha-pregn-4-en-20-yno(2,3-d)isoxazol-17-ol) using pregnant guinea pig plasma via openalex
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- Hormonal changes associated with Danazol therapy via openalex
- Pituitary gonadotropin inhibitory activity of danazol via openalex
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- doi:10.1016/0002-9378(73)90284-6 via openalex
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Cited by (28)
- The use of an oral contraceptive containing estradiol valerate and dienogest before office operative hysteroscopy: a feasibility study 2012
- Danazol regulates the functions of normal human endometrial stromal cell subpopulations by modifying endometrial cytokine networks 2009
- A benefit-risk assessment of medical treatment for uterine leiomyomas 2002
- Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology 1998
- Changing concepts of medical treatment of endometriosis 1993
- Endometrial patterns during therapy with danazol or gestrinone for endometriosis: structural and ultrastructural study 1992
- Medical treatment of mild endometriosis associated with infertility 1991
- Steroidal drugs in endometriosis 1989
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis after conservative surgery 1987
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis 1987
- Direct biphasic effects of danazol on gonadotropin-dependent differentiation of cultured rat granulosa cells 1986
- Steroidal regulation of endometriosis tissue: lack of induction of 17 beta-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol 1985
- Ultrastructural changes in endometriotic tissue during danazol treatment 1985
- Endometriosis 1984
- Cytosol estrogen and progestin receptor concentrations and 17 beta-hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue. Effects of hormonal treatment 1984
- The interaction of human endometrial and myometrial steroid receptors with danazol 1983
- Danazol 1982
- Changes of prolactin secretion following long-term danazol application 1981
- Ultrastructural changes in endometriotic tissue during danazol treatment 1981
- Dosage aspects of danazol therapy in endometriosis: short-term and long-term effectiveness 1981
- Review: The mechanism of action of danazol, a novel steroid derivative 1980
- Pharmacology and pharmacokinetics of danazol 1980
- The effect of danazol on the pituitary function, thyroid function, and mastodynia 1980
- The effect of danazol on menorrhagia, coagulation mechanisms, haematological indices and body weight 1979
- Danazol--a steroid with a unique combination of actions 1979
- Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity 1979
- Antigonadotropin (danazol) in the treatment of endometriosis. Evaluation of posttreatment fertility and three-year follow-up data 1978
- Danazol as a Luteolytic Agent 1978
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