Effect of vitamin C on the growth of experimentally induced endometriotic cysts

Yıldırım Durak, Durak Y, Yildirim Durak, Kokcu A, Arif Kökçü, Arif Kokcu, Kefeli M, Mehmet Kefeli, Bildircin D, Devran Bildircin, Devran Bıldırcın, Çelik H, Handan Çelik, Tayfun Alper, Alper T
Journal of Obstetrics and Gynaecology Research · 2013 · vol. 39(7) , pp. 1253–1258 · doi:10.1111/jog.12050 · PMID:23718930 · W1500020035
Lab / animal OA: closed CC0 ⤵ 26 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study found that vitamin C supplementation in rats dose-dependently reduced the volume and weight of experimentally induced endometriotic cysts and decreased natural killer cell content.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

AIM: The aim of this study was to investigate the effect of vitamin C on the growth of experimental endometriotic cysts. MATERIAL AND METHODS: The endometrium of the uterine horn wall (diameter, 4 mm) was implanted onto the inner surface of the anterior abdominal wall of 40 Wistar albino adult female rats, by laparotomy. The day after the implantation, the rats were randomly assigned into four groups (control group and experimental groups [V1, V2, and V3]) comprising 10 rats each. For 6 weeks, the control group (Group C) received 1 mL distilled water, whereas the experimental groups (Groups V1, V2, and V3) received 0.5 mg, 1.25 mg, and 2.5 mg of vitamin C in 1 mL of distilled water, respectively. The doses were given via oral gavage once per day. At the end of the administration, a second laparotomy was performed and endometriotic cyst volumes and weights of rats among the groups were compared. In addition, the stromal and glandular tissue and the natural killer cell contents of the cysts were compared among the groups. RESULTS: The cyst volume in Group V3 and the cyst weights in Groups V2 and V3 were significantly lower than those in Group C. The natural killer cell content in Groups V1, V2, and V3 was significantly lower than that in Group C. Stromal and glandular tissue contents of the groups were not significantly different. CONCLUSIONS: The dose-dependent vitamin C supplementation significantly reduced the volumes and weights of the endometriotic cysts.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Antioxidants Ascorbic Acid Dietary Supplements Dietary Supplements Disease Models, Animal Disease Models, Animal Endometriosis Abdominal Wall Abdominal Wall Animals Animals Antioxidants Antioxidants Ascorbic Acid Ascorbic Acid Cysts Cysts Cysts Cysts Cysts

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (27)

Source provenance

europepmc
last seen: 2026-10-11T09:27:45.537177+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:11:59.585523+00:00
unpaywall
last seen: 2026-10-17T06:24:38.187582+00:00
License: CC0 · commercial use OK