Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis
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Endometrial stromal cells from endometriosis implants and eutopic endometrium from women with endometriosis secreted significantly more IL-6 than normal endometrial cells under basal and IL-1 beta-stimulated conditions.
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Abstract
An in vitro model developed to compare human endometrial and endometriosis stromal cells was used to examine basal and stimulated expression of interleukin (IL-6). Stromal cells isolated from normal endometrium (NE) exhibited the lowest level of IL-6 secretion (84 pg/10(6) cells-48 h), whereas those cells isolated from endometriosis implants (EI) secreted the highest concentration of this inflammatory cytokine (46,284 pg/10(5) cells-48 h; P < 0.01). Eutopic endometrial stromal cells from women with endometriosis (EE) expressed an intermediate concentration of IL-6 (831 pg/10(6) cells-48 h). Stimulation of the various cultures with IL-1 beta dramatically augmented stromal cell production of IL-6. The mean concentrations of stimulated IL-6 secretion were 16,257, 37,800, and 264,290 pg/10(5) cells-48 h for NE, EE, and EI cells, respectively (P < 0.03). Exposure of the cell cultures to 10 nmol/L estradiol had little direct effect on IL-6 production. The results indicate that endometrial stromal cells isolated from tissues of women with and without endometriosis express IL-6 under basal and cytokine-stimulated conditions. Differential responsiveness among the three cell sources indicates that NE, EE, and EI cells have intrinsic quantitative differences in cytokine regulation.
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Cited by (50)
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- All-trans retinoic acid inhibits epithelial-to-mesenchymal transition (EMT) through the down-regulation of IL-6 in endometriosis 2021
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- Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells 2020
- Endometriosis 2019
- Eutopic endometrium from patients with endometriosis modulates the expression of CD36 and SIRP-α in peritoneal macrophages 2019
- Avaliação das células iNKT em pacientes com endometriose 2019
- The CCL17-CCR4 axis between endometrial stromal cells and macrophages contributes to the high levels of IL-6 in ectopic milieu 2017
- Estrogen Biosynthesis and Its Regulation in Endometriosis 2017
- Evaluation of estrogen in endometriosis patients: Regulation of GATA-3 in endometrial cells and effects on Th2 cytokines 2016
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- Endometriosis and ovarian cancer: links, risks, and challenges faced 2015
- Peroxisome proliferator-activated receptor γ agonist suppresses human telomerase reverse transcriptase expression and aromatase activity in eutopic endometrial stromal cells from endometriosis 2013
- Correction: IL-6 and Mouse Oocyte Spindle 2012
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- Endometriosis: Diagnosis and Treatment: From Fingernails to the Robot 2012
- Role of Steroid Hormones: Estrogen and Endometriosis 2011
- Die Pathophysiologie von Endometriose und Adenomyose. Morphologische, funktionelle und molekularbiologische Grundlagen 2011
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- A new concept of endometriosis and adenomyosis: tissue injury and repair (TIAR) 2011
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- Risk Factors for Endometriosis in a German Case-Control Study 2011
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- Attachment to extracellular matrices is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis 2010
- Nuclear factor kappaB pathway and interleukin-6 are affected in eutopic endometrium of women with endometriosis 2009
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- Proliferação e apoptose em endométrio tópico e ectópico de pacientes com endometriose peritoneal, ovariana e de septo reto-vaginal 2007
- Avaliação das concentrações das interleucinas 1-beta e 6 e da proteína amilóide A, no líquido peritoneal e no soro de pacientes com endometriose pélvica 2007
- Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis 2007
- Endometriosis as a model for inflammation-hormone interactions in ovarian and breast cancers 2006
- Endometriosis: harmful survival of an ectopic tissue 2006
- Peritoneal fluid and serum levels of hepatocyte growth factor may predict the activity of endometriosis 2006
- Endometriosis and inflammation in infertility 2004
- Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis 2004
- EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis 2004
- Endometriosis and inflammation in infertility 2004
- Immunological and endocrinological studies on lymphocyte subpopulation and medical treatment for infertility in patients with endometriosis 2003
- Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells 2003
- Peritoneal fluid concentrations of ciliary neurotrophic factor, a gp130 cytokine, in women with endometriosis 2003
- Noninvasive diagnosis of endometriosis: the role of imaging and markers 2003
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