Increased activation of nuclear factor-kappa B (NF-kappaB) in isolated peritoneal macrophages of patients with endometriosis

Jean-Christophe Lousse, Lousse JC, Jean‐Christophe Lousse, Van Langendonckt A, Anne Van Langendonckt, González-Ramos R, Reinaldo González-Ramos, Defrère S, Sylvie Defrère, Renkin E, Emmanuelle Renkin, Donnez J, Jacques Donnez
Fertility and sterility · 2007 · vol. 90(1) , pp. 217–220 · doi:10.1016/j.fertnstert.2007.06.015 · PMID:17889859 · W2085484171
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This study investigated the activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages from endometriosis patients and found increased levels compared to controls.

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Abstract

Endometriosis is characterized by pelvic inflammation that shows an increased number of activated peritoneal macrophages and their secreted products such as cytokines, growth factors, and angiogenic factors. Our results show that activation of nuclear factor-kappa B (NF-kappaB), a pro-inflammatory transcription factor, is statistically significantly increased in peritoneal macrophages from patients with endometriosis when compared with controls.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Macrophage Activation Macrophage Activation Macrophages, Peritoneal Transcription Factor RelA Adult Adult Case-Control Studies Case-Control Studies Cell Nucleus Cell Nucleus Cell Nucleus Endometriosis Endometriosis Female Female Humans Humans Immunohistochemistry Immunohistochemistry

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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