Adhesion of human endometrial fragments to peritoneum in vitro

P G Groothuis, Patrick G. Groothuis, C A Koks, Carolien A.M. Koks, A F de Goeij, Anton F.P.M. de Goeij, Gerard A.J. Dunselman, G A Dunselman, Jan Willem Arends, J W Arends, J L Evers, J.L.H. Evers
Fertility and sterility · 1999 · vol. 71(6) , pp. 1119–1124 · doi:10.1016/s0015-0282(99)00122-3 · PMID:10360921 · W2171471341
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This study investigated the adhesion of human endometrial fragments to peritoneal tissue under in vitro conditions to understand mechanisms of endometriosis development.

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Abstract

OBJECTIVE: To evaluate the adhesion of endometrial fragments obtained during the proliferative phase of the menstrual cycle to fresh human peritoneum obtained during abdominal surgery. DESIGN: A prospective, descriptive, morphologic and cell biologic study. SETTING: Tertiary care university medical center. PATIENT(S): Six female volunteers. INTERVENTION(S): After endometrial biopsies performed during diagnostic laparoscopy, endometrial fragments were generated by enzymatic digestion and mechanical separation. Peritoneum was obtained during abdominal operations for benign indications. MAIN OUTCOME MEASURE(S): Adhesion of endometrial fragments was studied by histologic examination and scanning and transmission electron microscopy. RESULT(S): After incubation, the mesothelium was intact in some areas, whereas in other areas mesothelial cells were damaged or absent. Adhesion of endometrial fragments was observed only at locations where the basement membrane was exposed. In areas largely denuded of mesothelial cells, endometrial fragments spread over the basement membrane to form monolayers. CONCLUSION(S): Human peritoneum is suitable for studying the adhesion of endometrial fragments. Intact mesothelium prevents the adhesion of endometrial fragments, suggesting that trauma to the mesothelial lining is a prerequisite for endometrial cell adhesion.

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MeSH descriptors

Cell Adhesion Endometrium Peritoneum Peritoneum Basement Membrane Basement Membrane Endometrium Endometrium Epithelial Cells Epithelial Cells Epithelium Epithelium Female Humans In Vitro Techniques Microscopy, Electron Microscopy, Electron, Scanning Prospective Studies

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