Stromal vascularization in the endometrium during adenomyosis

Hirotaka Ota, Ota H, Tanaka T, Toshinobu Tanaka
Microscopy research and technique · 2003 · vol. 60(4) , pp. 445–449 · doi:10.1002/jemt.10282 · PMID:12567401 · W2000976989
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Endometrial vascularization in adenomyosis patients showed irregular, dilated vessels and significantly increased capillary surface area compared to fertile women, potentially explaining hypermenorrhea.

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Abstract

In adenomyosis, the two major frequent symptoms are hypermenorrhea and dysmenorrhea. The incidence of the former is said to be high, ranging from 36 to 70%. It has been found that vascular distribution of the endometrium in adenomyosis is diversely different from fertile patients without adenomyosis. For example, hysteroscopy revealed that approximately half of the patients have abnormal vascularization. In these patients, vascular distribution was generally irregular, and vessels were thick, dilated, and/or reticular in some patients. Moreover, morphometric analysis of the endometrium revealed that in the fertile women, the mean surface area, total surface area, and total number of capillaries, all increased significantly in the secretory phase compared to the proliferative phase. In contrast, the above parameters increased in the adenomyosis group in both the proliferative phase and secretory phase compared to the fertile women. In particular, the total surface area of capillaries per mm(2) markedly rose, by 11.6 times, compared to that of the proliferative phase in the fertile women. These findings suggest that regulatory factors involved in the vascular proliferation are diversely exaggerated, and that the abnormal vascularization of the endometrium is closely related with hypermenorrhea.

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Condition tags

endometriosisadenomyosisdysmenorrhea

MeSH descriptors

Endometriosis Endometrium Endometrium Neovascularization, Pathologic Neovascularization, Pathologic Capillaries Capillaries Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Menorrhagia Menorrhagia Menorrhagia Menstrual Cycle

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (31)

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