Eicosanoids production in endometriosis

Haruki Koike, H Koike, Koike H, Hiromu Egawa, Egawa H, H Egawa, T Ohtsuka, Takashi Ohtsuka, Ohtsuka T, Yamaguchi M, Motoko Yamaguchi, M. Yamaguchi, T Ikenoue, Tsuyomu Ikenoue, Ikenoue T, N. Mori, Naoko Mori, Mori N
Prostaglandins, leukotrienes, and essential fatty acids · 1992 · vol. 45(4) , pp. 313–317 · doi:10.1016/0952-3278(92)90089-2 · PMID:1603821 · W2006157819
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This study investigated eicosanoid production in endometriosis and identified specific eicosanoids that were altered in the condition.

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Abstract

In order to investigate the production of eicosanoids in human endometrium, myometrium, leiomyoma, adenomyosis, normal ovary, non-endometrial cyst and endometrial cyst, slices of each tissue were incubated. 6-Keto-prostaglandin (PG) F1 alpha, thromboxane (TX) B2, PGF2 alpha and PGE2 concentrations in the incubation medium were measured by direct RIA. 6-Keto-PGF1 alpha production of adenomyosis was significantly higher than that of endometrium, myometrium and leiomyoma, especially in the menstrual phase. The production of eicosanoids in endometrial cyst was significantly higher than that of non-endometrial cyst and normal ovary. These results suggest that endometriosis is associated with increased eicosanoid production in vivo.

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Condition tags

endometriosis

MeSH descriptors

Eicosanoids Endometriosis 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha Adult Cysts Cysts Dinoprost Dinoprost Dinoprostone Dinoprostone Eicosanoids Endometriosis Female Humans Leiomyoma Leiomyoma Middle Aged Myometrium Myometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (9)

Source provenance

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