Novel dietary supplement association reduces symptoms in endometriosis patients

Pietro G. Signorile, Signorile PG, Rosa Viceconte, Viceconte R, Alfonso Baldi
Journal of cellular physiology · 2017 · vol. 233(8) , pp. 5920–5925 · doi:10.1002/jcp.26401 · PMID:29243819 · W2772907093
Non-randomised trial OA: closed CC0 ⤵ 54 in-corpus citations
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A 3-month dietary supplement of quercetin, curcumin, parthenium, nicotinamide, 5-methyltetrahydrofolate, and omega 3/6 significantly reduced endometriosis symptoms, PGE2, and CA-125 levels compared to controls.

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Abstract

Endometriosis is characterized by disabling symptoms that afflict young women with severe physical discomfort, difficulty in relationship life, and infertility; however, the currently available therapeutic strategies are unsatisfactory. Goal of this research was to identify a new combination of natural active ingredients that, administered as dietary supplements, could have the effect of reducing inflammatory response in endometriosis patients, decreasing the symptoms the disease produces and its harmful effects on affected organs. A cohort of endometriosis patient was treated for 3 months with a composition including quercitin, curcumin, parthenium, nicotinamide, 5-methyltetrahydrofolate, and omega 3/6. Using a VAS scale, we demonstrated a significant reduction of the symptoms in endometriosis patients treated with the dietary composition respect to the controls. Moreover, we demonstrated also a significant reduction in the serum levels of PGE2 and CA-125. Further study are required to compare the effect of this combination of molecules with standard therapies and to evaluate if the use of these dietary supplements in combination with standard therapies may lead to the improvement of the regular medical treatment for endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Dietary Supplements Dietary Supplements Endometriosis Pain Plant Extracts Adult Adult Curcumin Curcumin Curcumin Endometriosis Endometriosis Endometriosis Fatty Acids, Omega-3 Fatty Acids, Omega-3 Fatty Acids, Omega-3 Fatty Acids, Omega-6 Fatty Acids, Omega-6 Fatty Acids, Omega-6 Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (50)

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