Prototype of Multiplex Bead Assay for Quantification of Three Serum Biomarkers for In Vitro Diagnosis of Endometriosis

Pietro Giulio Signorile, Pietro G. Signorile, Alfonso Baldi
Journal of cellular physiology · 2016 · vol. 231(12) , pp. 2622–2627 · doi:10.1002/jcp.25410 · PMID:27137486 · W2346252002
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Researchers developed a multiplex bead assay to quantify three serum biomarkers (Zn-alpha2-glycoprotein, albumin, and complement C3) for endometriosis diagnosis, confirming its value in a small patient cohort.

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Abstract

Endometriosis is a very common disease, affecting 10% of women in the reproductive age. To date, a significant delay between onset of the symptoms and definitive diagnosis is caused by the lack of a reliable non-invasive diagnostic test. Recently, the potential value as diagnostic markers for endometriosis of three proteins (Zn-alpha2-glycoprotein, serum albumin, and complement C3 precursor), has been showed. In this article, we have defined the experimental conditions for the development of a multiplex bead array assay for rapid and simultaneous quantification of these three biomarkers in the serum of patients with endometriosis. Finally, pivotal experiments on a small cohort of patients have confirmed the diagnostic value of this assay. J. Cell. Physiol. 231: 2622-2627, 2016. © 2016 Wiley Periodicals, Inc.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Biological Assay Biomarkers Endometriosis Endometriosis Adipokines Adult Biological Assay Biomarkers Calibration Carrier Proteins Carrier Proteins Case-Control Studies Complement C3 Complement C3 Endometriosis Female Glycoproteins Glycoproteins Humans Protein Binding

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