Prototype Salivary Assay for Quantification of Two Biomarkers for In Vitro Diagnosis of Endometriosis

Pietro Giulio Signorile, Pietro G. Signorile, Sabrina Dominici, Rosa Viceconte, Alfonso Baldi
Critical reviews in eukaryotic gene expression · 2024 · vol. 34(4) , pp. 25–31 · doi:10.1615/critreveukaryotgeneexpr.2023051116 · PMID:38505870 · W4390714166
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study developed an ELISA assay to quantify Zn-alpha2-glycoprotein and complement C3 precursor in saliva, demonstrating its potential for noninvasive endometriosis diagnosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This paper describes development of a simple ELISA-based salivary assay to quantify two previously proteomics-identified serum endometriosis biomarkers, Zn-alpha2-glycoprotein and complement C3 precursor, adapting them for rapid measurement in saliva. In a preliminary small cohort of patients and controls, the authors report that the assay shows potential diagnostic value. A key limitation explicitly acknowledged in the study is the preliminary nature of testing in a small number of participants, rather than validation in a large independent dataset. This paper is centrally about endometriosis — it focuses on a prototype noninvasive salivary ELISA diagnostic approach using endometriosis biomarker quantification.

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Abstract

Endometriosis, a very common disease in women, is characterized by endometrial structures outside the uterine cavity. The lack of a reliable noninvasive diagnostic test and the often nonspecific symptoms of this pathology are responsible for the delay in definitive diagnosis of this disease. Recently, through a proteomics approach, our research group has identified two potential diagnostic markers for endometriosis in serum (Zn-alpha2-glycoprotein and complement C3 precursor). In this article, we describe the experimental conditions of a simple ELISA for rapid quantification of these two biomarkers in the saliva of patients with endometriosis. Finally, preliminary experiments on a small cohort of patients and controls have confirmed the potential diagnostic value of this assay.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Biomarkers Biomarkers Biomarkers Biomarkers Biomarkers Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female Female Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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