Clinical and Pathological Findings of Suspected Cases of Peritoneal Endometriotic Lesions

Aneela Siddiqui, Hamda Shah, Sumera Brohi, Urwa Sarwar, Arjumand, Imran Baig
In: Pakistan Journal of Medical and Health Sciences · 2022 · vol. 16(4) , pp. 1162–1164 · doi:10.53350/pjmhs221641162 · W4283754996
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study examined 88 suspected peritoneal endometriotic lesions, finding dysmenorrhea most common and confirming endometriosis in 45.5%, with HLM and pseudodecidualization more frequent in diagnostic biopsies.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This cross-sectional observational study evaluated 88 women aged 18–55 presenting with suspected peritoneal endometriotic lesions at Shaikhzaid women hospital (Jan to Jun 2021), using demographic and symptom data plus endometriotic biopsies analyzed with mixed effects logistic regression to account for multiple gland patterns. Dysmenorrhea (36.4%) and deep dyspareunia (29.5%) were the most common symptoms, and pathological findings showed endometriosis in 45.5% of cases; most biopsies were undiagnostic (65.9%) with chronic inflammation, dystrophic calcifications, hemosiderin-laden macrophages, vascular proliferation, and adhesions reported among these. HLM and pseudodecidualization were more often seen in diagnostic biopsies, and blue/black clinical appearances were also associated with diagnostic biopsies. This paper is centrally about endometriosis—specifically the clinical and pathological findings of suspected peritoneal endometriotic lesions.

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Abstract

Objective: The purpose of this study is to determine the clinical and pathological findings of suspected cases of peritoneal endometriotic lesions. Study Design: Cross-sectional/Observational study Place and Duration: Shaikhzaid women hospital larkana, From: Jan, 2021 to June, 2021 Methods: There were 88 females were presented in this study. Females were aged between 18-55 years. Informed permission was obtained before obtaining demographic information such as age, BMI, and symptoms. Included patients had confirmed peritoneal endometriotic lesions. All the suspected cases of peritoneal endometriotic lesion were underwent for biopsies. Numerous endometriotic biopsies were analyzed using mixed effects logistic regression in order to account for various patients and multiple endometriotic gland patterns. Pathological and clinical outcomes among cases were measured. We used SPSS 21.0 to analyze complete data. Results: Among 88 cases, 30 (34.1%) were aged between 18-28 years, 37(42.05%) were aged between 29-38 years and the rest were 21 (23.9%) were aged > 38 years. Mean BMI of the females was 23.2±14.25 kg/m2. Dysmenorrhea was the most common symptoms found in 32 (36.4%) cases, followed by deep dyspareunia in 26 (29.5%) cases, chronic pelvic pain in 18 (20.5%) cases and painful defecation in 12 (13.6%) cases. Frequency of endometriosis was 40 (45.5%) by pathological findings. Majority was undiagnostic biopsies among 58 (65.9%) cases and diagnostic biopsies were among 30 (34.1%) cases. Among undiagnostic biopsies, chronic inflammation found in 18 (31.03%), dystrophic calcifications in 15 (25.9%) cases, hemosiderin-laden macrophages (HLM) in 13 (22.4%) cases, vascular proliferation 10 (17.2%) and adhesions were 10 (17.2%). HLM (P=0.002) and pseudodecidualization (P=0.03) were more often seen in diagnostic biopsies (P=0.05) as were blue/black clinical appearances (P=0.03). Conclusion: We found that individuals with a strong clinical suspicion of endometriosis show a variety of histologic abnormalities, with fewer than half satisfying current histopathologic criteria. Given the diverse histopathologic appearance, more study may be necessary, especially for lesions with primarily vascular characteristics. Keywords: Peritoneal Endometriotic Lesions, Symptoms, Endometriosis, Biopsy, HLM
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Objective

The purpose of this study is to determine the clinical and pathological findings of suspected cases of peritoneal endometriotic lesions. Study Design: Cross-sectional/Observational study Place and Duration: Shaikhzaid women hospital larkana, From: Jan, 2021 to June, 2021

Methods

There were 88 females were presented in this study. Females were aged between 18-55 years. Informed permission was obtained before obtaining demographic information such as age, BMI, and symptoms. Included patients had confirmed peritoneal endometriotic lesions. All the suspected cases of peritoneal endometriotic lesion were underwent for biopsies. Numerous endometriotic biopsies were analyzed using mixed effects logistic regression in order to account for various patients and multiple endometriotic gland patterns. Pathological and clinical outcomes among cases were measured. We used SPSS 21.0 to analyze complete data.

Results

Among 88 cases, 30 (34.1%) were aged between 18-28 years, 37(42.05%) were aged between 29-38 years and the rest were 21 (23.9%) were aged > 38 years. Mean BMI of the females was 23.2±14.25 kg/m2. Dysmenorrhea was the most common symptoms found in 32 (36.4%) cases, followed by deep dyspareunia in 26 (29.5%) cases, chronic pelvic pain in 18 (20.5%) cases and painful defecation in 12 (13.6%) cases. Frequency of endometriosis was 40 (45.5%) by pathological findings. Majority was undiagnostic biopsies among 58 (65.9%) cases and diagnostic biopsies were among 30 (34.1%) cases. Among undiagnostic biopsies, chronic inflammation found in 18 (31.03%), dystrophic calcifications in 15 (25.9%) cases, hemosiderin-laden macrophages (HLM) in 13 (22.4%) cases, vascular proliferation 10 (17.2%) and adhesions were 10 (17.2%). HLM (P=0.002) and pseudodecidualization (P=0.03) were more often seen in diagnostic biopsies (P=0.05) as were blue/black clinical appearances (P=0.03).

Conclusion

We found that individuals with a strong clinical suspicion of endometriosis show a variety of histologic abnormalities, with fewer than half satisfying current histopathologic criteria. Given the diverse histopathologic appearance, more study may be necessary, especially for lesions with primarily vascular characteristics.

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Condition tags

endometriosischronic_pelvic_paindysmenorrheadyspareunia

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