Prototype of Multiplex Bead Assay for Quantification of Three Serum Biomarkers for In Vitro Diagnosis of Endometriosis

Pietro Giulio Signorile, Pietro G. Signorile, Signorile PG, Alfonso Baldi
Journal of cellular physiology · 2016 · vol. 231(12) , pp. 2622–2627 · doi:10.1002/jcp.25410 · PMID:27137486 · W2346252002
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Researchers developed a multiplex bead assay to quantify three serum biomarkers (Zn-alpha2-glycoprotein, albumin, and complement C3) for endometriosis diagnosis, confirming its value in a small patient cohort.

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Abstract

Endometriosis is a very common disease, affecting 10% of women in the reproductive age. To date, a significant delay between onset of the symptoms and definitive diagnosis is caused by the lack of a reliable non-invasive diagnostic test. Recently, the potential value as diagnostic markers for endometriosis of three proteins (Zn-alpha2-glycoprotein, serum albumin, and complement C3 precursor), has been showed. In this article, we have defined the experimental conditions for the development of a multiplex bead array assay for rapid and simultaneous quantification of these three biomarkers in the serum of patients with endometriosis. Finally, pivotal experiments on a small cohort of patients have confirmed the diagnostic value of this assay. J. Cell. Physiol. 231: 2622-2627, 2016. © 2016 Wiley Periodicals, Inc.

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Condition tags

endometriosis

MeSH descriptors

Biological Assay Biomarkers Endometriosis Endometriosis Adipokines Adipokines Adult Adult Biological Assay Biological Assay Biomarkers Biomarkers Calibration Calibration Carrier Proteins Carrier Proteins Carrier Proteins Case-Control Studies Case-Control Studies Complement C3

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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