Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antimüllerian hormone level modifications

Edgardo Somigliana, Nicola Berlanda, Laura Benaglia, Paola Viganò, Paolo Vercellini, Luigi Fedele
Fertility and sterility · 2012 · vol. 98(6) , pp. 1531–1538 · doi:10.1016/j.fertnstert.2012.08.009 · PMID:22975114 · W1999151418
Systematic review / meta-analysis OA: closed CC0 ⤵ 280 in-corpus citations
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This systematic review examined studies on serum anti-Müllerian hormone (AMH) levels following surgical excision of endometriomas to assess changes in ovarian reserve.

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Abstract

OBJECTIVE: To evaluate serum antimüllerian hormone (AMH) level modification after surgical excision of ovarian endometriomas. DESIGN: Systematic review. MEDLINE search from January 1990 to April 2012 using the combination of medical terms endometriosis, endometrioma, endometriotic cyst, and AMH or antimüllerian hormone, MIF or müllerian inhibiting factor. Reference lists of selected studies were checked for additional potential contributions. SETTING: Not applicable. PATIENT(S): Women with ovarian endometriomas requiring surgery. INTERVENTION(S): Serum AMH level assessment. MAIN OUTCOME MEASURE(S): Serum AMH level modifications. RESULT(S): Eleven articles satisfied our selection criteria. Data pooling were deemed inopportune owing to the heterogeneity of the study designs and of the reported parameters. Nine of 11 studies documented a statistically significant reduction of serum AMH level after surgery. The two studies failing to document this decrease were published by the same study group and partly overlapped. The magnitude of the decline was more evident in women operated on for bilateral endometriomas. CONCLUSION(S): Evidence deriving from the evaluation of serum AMH level modifications after surgical excision of endometriomas supports a surgery-related damage to ovarian reserve.

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Condition tags

endometriosis

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Endometriosis Oocytes Ovarian Diseases Ovarian Diseases Anti-Mullerian Hormone Anti-Mullerian Hormone Cell Count Cell Count Cell Count Endometriosis Endometriosis Female Female Humans Humans Oocytes Oocytes Ovarian Diseases

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (41)

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