Effect of vasopressin injection technique on ovarian reserve during laparoscopic cystectomy of ovarian endometriomas: a systematic review and meta-analysis of randomized controlled trials

Saeed Baradwan, Majed Saeed Alshahrani, Majed S Alshahrani, Rayan Al Sghan, Hussein Sabban, Khalid Khadawardi, Nabigah Alzawawi, Hanin Hassan Abduljabbar, Hanin H Abduljabbar, Ahmed M Abdelhakim, Ahmed Mohamed Abdelhakim, Abdulhadi A Al Amodi, Amira Fouad Elgamel, Amira F Elgamel
Minerva obstetrics and gynecology · 2024 · vol. 76(4) , pp. 386–394 · doi:10.23736/s2724-606x.23.05310-1 · PMID:38576336 · W4393988194
meta-analysis OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Vasopressin injection during laparoscopic ovarian endometrioma cystectomy reduced blood loss and coagulation events, and preserved ovarian reserve as indicated by improved AMH and reduced FSH levels.

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Abstract

INTRODUCTION: To evaluate the effect of injecting vasopressin during laparoscopic excision of ovarian endometriomas on ovarian reserve. EVIDENCE ACQUISITION: Four different databases (PubMed, Cochrane Library, Scopus, and ISI Web of Science) were searched to identify relevant studies in March 2023. We selected randomized controlled trials (RCTs) that compared vasopressin injection in the intervention group versus no injection of vasopressin in the control group among women undergoing laparoscopic cystectomy of ovarian endometriomas. The main outcomes were the amount of bleeding, number of coagulation events, and levels of serum anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH). The available data were extracted and analyzed in a meta-analysis model using RevMan software. EVIDENCE SYNTHESIS: Seven RCTs, involving a total number of 478 patients, were included in our study. The vasopressin group had significantly reduced blood loss amount and number of coagulation events compared to the control group (P=0.004 and P=0.005). There was a significant improvement in the AMH levels within 6 months after surgery in the vasopressin group (MD=0.52, 95% CI: 0.11, 0.93, P=0.01). In addition, the FSH levels within 6 months after laparoscopic cystectomy were significantly reduced with vasopressin injection. CONCLUSIONS: Vasopressin injection during laparoscopic cystectomy of ovarian endometriomas is effective in reducing blood loss amount and frequency of coagulation, as well as protecting the ovarian reserve. More trials are encouraged to confirm our findings.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Laparoscopy Laparoscopy Laparoscopy

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SciLite annotations

chemicals 5
vasopressin vasopressin vasopressin vasopressin vasopressin

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