Morphometric evaluation of stromal vascularization in the endometrium in adenomyosis
Observational
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⤵ 34 in-corpus citations
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This study retrospectively quantified endometrial stromal vascularization in adenomyosis patients, finding it markedly increased compared to controls, especially in the proliferative phase.
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Abstract
A computerized morphometric investigation of stromal vascularization in the endometrium during adenomyosis was performed retrospectively. Using a polyclonal antibody and a peroxidase-antiperoxidase method, formalin-fixed paraffin sections of the tissue were stained for von Willebrand factor, a marker for endothelium. The subjects were divided into two groups: 42 patients with histologically proven adenomyosis and 29 fertile control subjects, 12 in the proliferative phase and 17 in the secretory phase. Objective quantitative colour image analysis was used to assess the staining intensity and hence the degree of vascularization. In the control group, stromal vascularization increased in the secretory phase. In adenomyosis, vascularization increased markedly, up to 11.6 times that of the controls, in terms of the in total surface area of capillaries per mm2 in the endometrium in the proliferative phase. These findings suggest clinical relevance to severe functional disturbances such as hypermenorrhoea or iron deficiency anaemia.
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Cited by (34)
- Adenomyosis and Endometriosis: Two Faces of the Same Disease? 2026
- Correlations between TSC Expression and Menorrhagia in Adenomyosis Patients 2026
- Increased Angiogenesis and Lymphangiogenesis in Adenomyosis Visualized by Multiplex Immunohistochemistry 2022
- Adenomyosis: Mechanisms and Pathogenesis 2020
- Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review 2019
- Benign Uterine Diseases 2019
- Adenomyosis and Hysteroscopy: An Up-to-Date Review 2017
- Adenomyosis and Hysteroscopy: An Up-to-Date Review 2017
- The effect of adenomyosis on the outcomes of laparoscopic hysterectomy 2016
- Assessment of uterine, subendometrial blood flows and endometrial gland vascular endothelial growth factor (EG-VEGF) in women with unexplained infertility 2014
- Constitutive and tumor necrosis factor-α-induced activation of nuclear factor-κB in adenomyosis and its inhibition by andrographolide 2013
- Alteration in Endometrial Remodeling: A Cause for Implantation Failure in Endometriosis? 2012
- Increased immunoreactivity to SLIT/ROBO1 and its correlation with severity of dysmenorrhea in adenomyosis 2010
- An investigation of basic science and clinical research methodologies to benefit clinical practice 2009
- Potential clinical applications of uterine artery occlusion 2009
- Expression of cyclooxygenase-2 and matrix metalloproteinase-2 in adenomyosis and endometrial polyps and its correlation with angiogenesis 2009
- Expression of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1alpha (HIF-1alpha), and microvessel density in endometrial tissue in women with adenomyosis 2009
- Uterine artery embolization for the treatment of adenomyosis 2008
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- Probucol, a hypocholesterolemic agent, prevents the development of uterine adenomyosis induced by pituitary grafting in mice 2004
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- Human uterine vascular structures in normal and diseased states 2003
- Adenomyosis: MRI of the uterus treated with uterine artery embolization 2003
- Stromal vascularization in the endometrium during adenomyosis 2003
- Effects of angiogenesis inhibitor TNP-470 on the development of uterine adenomyosis in mice 2003
- Increased microvessel density in adenomyosis uteri 2001
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