Maria I Yarmolinskaya

External genital endometriosis is a chronic inflammatory disease affecting 10% of women of reproductive age, characterized by neoangiogenesis in endometriotic implants, which is controlled by a variety of factors. Recently, a great deal of …

Background: Endometriosis is a complex condition that impairs women's quality of life and reproductive potential. Its diagnosis remains significant challenge for clinicians. The aim of the study was to investigate cancer-like immune evasion…

The study of the expression of proliferation factors by immunohistochemistry is necessary to determine their role in the pathogenesis of the disease and to develop new diagnostic methods and pathogenetically based therapy. Aim of the study …

Background: Timely diagnosis of adenomyosis remains important due to the high incidence of the disease among women of reproductive age. Interest in using myometrial transition zone parameters in diagnostic algorithms has persisted since the…

Background: Type 1 diabetes mellitus and endometriosis significantly reduce the quality of patient’s life and hinder the implementation of reproductive plans. Studying the features of the clinical course of endometriosis in patients with ty…

BACKGROUND: The creation of an experimental model of adenomyosis is of scientific and practical interest, which allows for the evaluation of the effectiveness and pathogenetically substantiated therapy of adenomyosis in the future on the cr…

BACKGROUND: Endometriosis affects 5–10% of women of reproductive age worldwide. Despite the high prevalence of the disease, its diagnosis is usually delayed for several years and misdiagnosis is common, leading to delay in effective pathoge…

The synthetic progestogen dienogest has been closely studied in recent years for its therapeutic efficacy in endometriosis. Despite its benign nature, this disease is a serious problem due to its widespread prevalence and negative impact on…

BACKGROUND: This article presents the second stage of the study to evaluate the efficacy and tolerability of new directions of drug therapy for adenomyosis based on an experimental model of the disease. This stage is necessary for the furth…

Background: To date, the etiology and pathogenesis of endometriosis are still unclear and are determined by a number of factors (genetic, immunological and endocrine), including microbiological ones. Aim: The aim of this study was to charac…

BACKGROUND: Previous studies leave no doubt as to the involvement of kisspeptin and oxytocin in the pathogenesis of endometriosis. Oxytocin and kisspeptin levels in the peripheral blood of patients with endometriosis were shown to be higher…

Endometriosis is one of the most heterogeneous diseases in both its clinical manifestations and forms, and its course. Deep infiltrating endometriosis is a severe form of endometriosis, which currently occurs in every fifth patient with thi…

BACKGROUND: Uterine fibroids are hormone-dependent tumors in which the local microenvironment and the fibroid pseudocapsule play an important role. The oxytocin receptor, encoded by the OTR gene, may contribute to the regulation of contract…

Endometriosis is a common estrogen-dependent, chronic, inflammatory disease that has a negative impact on the getting pregnant, gestational process, and birth outcomes. Foci of endometriosis affect the processes of placentation and lead to …

Endometriosis is a chronic recurrent disease with insufficiently studied pathogenesis. Endometriosis is known to share similar features with tumors. Thus, the outgrowth of endometrium-like tissue outside the uterus is the main feature of th…

BACKGROUND: Vitamin A is a fat-soluble compound, which is a biologically inactive food form and undergoes transformation by cytosolic alcohol dehydrogenases and microsomal retinol dehydrogenases into retinaldehyde, followed by oxidation by …

BACKGROUND: The study of stress-induced phosphoprotein 1 in the pathogenesis of adenomyosis is not only of theoretical interest, but this protein may be also considered as a potential biomarker of the disease. AIM: The aim of this study was…

Background. Endometriosis is distinguished by its high prevalence and significant impact on the quality of life and reproductive health of women; however, its etiology and essential pathogenesis of remain uncertain so far. Modern research i…

BACKGROUND: An in-depth study of the pathogenesis of adenomyosis and the development of new therapeutic approaches are extremely relevant. Atosiban, a competitive oxytocin receptor antagonist, may be a promising drug with a potential therap…

Endometriosis is a genetic determined disease defined as the presence of endometrium-like tissue outside of the uterine cavity. Although the etiology of endometriosis remains elusive, immunological dysfunction and hormone imbalance are cons…

Pelvic pain is one of the most common and significant clinical symptoms of endometriosis. The complex pathogenesis and paradoxical nature of endometriosis-associated pain, its chronicity and centralization, a marked decrease in the quality …

BACKGROUND:External genital endometriosis is a multifactorial estrogen-dependent disease. Local estrogen production due to aromatase activity can play an important role in its pathogenesis, so aromatase inhibitors are considered promising d…

BACKGROUND: The prevalence of external genital endometriosis is high, yet there is insufficient understanding of its etiology and pathogenesis. This coupled with the challenges posed by its diagnosis and treatment, and its co-occurrence wit…

BACKGROUND: Endometriomas are most common during the reproductive years and have an extremely negative impact on ovarian reserve and fertility. In this case, the main method of treatment remains surgery, which inevitably injures healthy ova…

This article presents a modern review of the main classifications of adenomyosis based on the clinical course, the prevalence of the pathological process, the results of ultrasound and magnetic resonance imaging, and histological verificati…