Decrease in peripheral blood polymorphonuclear leukocyte chemotactic index in endometriosis: role of prostaglandin E2 release

Garzetti GG, G. G. Garzetti, A Ciavattini, Andrea Ciavattini, Mauro Provinciali, M Provinciali, M Amati, Amati M, M Muzzioli, Muzzioli M, M Governa, Governa M
Obstetrics and gynecology · 1998 · vol. 91(1) , pp. 25–29 · doi:10.1016/s0029-7844(97)00592-9 · PMID:9464715 · W3023023270
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Tamoxifen therapy in postmenopausal breast cancer patients alters insulin-like growth factor-1 and insulin-like growth factor-binding protein-1 expression in the endometrium, potentially contributing to its uterotropic effects.

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Abstract

OBJECTIVE: To investigate the effect of disease on peripheral blood polymorphonuclear leukocyte chemotactic index and natural killer cell cytotoxicity and to provide additional information concerning the cell-mediated immune function in endometriosis. METHODS: Chemotactic index of peripheral blood polymorphonuclear leukocytes, natural killer cell activity, and plasma estradiol (E2) and plasma prostaglandin (PG) E2 levels were evaluated in 46 women who underwent laparoscopy or laparotomy for pelvic pain, infertility, and/or benign adnexal masses. RESULTS: The 20 women (43%) with endometriosis showed a decrease in peripheral blood polymorphonuclear leukocyte chemotactic index, related to advanced disease stage (P < .001). A significant inverse correlation was observed between plasma PGE2 levels and chemotactic index in stage III and IV endometriosis (r = -.73, P = .004). Similarly, natural cytotoxicity was decreased significantly with respect to the stage of endometriosis (P = .004) and related inversely to plasma PGE2 levels (r = -.74, P = .003). A direct relationship was observed between PGE2 and plasma E2 levels (r = .59, P = .006). CONCLUSION: Advanced endometriosis is associated with decreased peripheral blood polymorphonuclear leukocyte chemotactic index and natural killer cytotoxicity, which may be related to plasma PGE2 and E2 levels.

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Condition tags

endometriosis

MeSH descriptors

Chemotaxis, Leukocyte Cytotoxicity, Immunologic Dinoprostone Endometriosis Estradiol Killer Cells, Natural Adult Adult Chemotaxis, Leukocyte Chemotaxis, Leukocyte Cytotoxicity, Immunologic Cytotoxicity, Immunologic Diagnostic Techniques and Procedures Diagnostic Techniques and Procedures Dinoprostone Dinoprostone Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

Cited by (12)

Source provenance

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