Expression and regulation of estrogen-converting enzymes in ectopic human endometrial tissue

Fechner S, Sabine Fechner, Bettina Husen, Husen B, Thole H, Hubert Thole, Markus Schmidt, M Schmidt, Schmidt M, Isabella Gashaw, Kimmig R, Rainer Kimmig, Elke Winterhager, Winterhager E, Grümmer R, Ruth Grümmer
Fertility and sterility · 2007 · vol. 88(4) , pp. 1029–1038 · doi:10.1016/j.fertnstert.2006.11.153 · PMID:17316633 · W2050798820
Lab / animal OA: bronze CC0 ⤵ 34 in-corpus citations
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This study investigated the expression and regulation of enzymes that convert androgens to estrogens within human ectopic endometrial tissue.

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Abstract

OBJECTIVE: To investigate the regulation of estrogen-converting enzymes in human ectopic endometrial tissue. DESIGN: Animal study. SETTING: Academic medical center. ANIMAL(S): Sixty female nude mice with implanted human endometrial tissue. PATIENT(S): Twenty-two premenopausal women undergoing endometrial biopsy or hysterectomy. INTERVENTION(S): Human endometrial tissue was implanted into the peritoneal cavity of nude mice, and the effect of therapeutic drugs on transcription of steroid receptors and estrogen-converting enzymes was analyzed. MAIN OUTCOME MEASURE(S): Transcript levels of steroid hormone receptors, 17beta-hydroxysteroid dehydrogenase type 1 and 2, aromatase, and steroid sulfatase as well as proliferation rate were analyzed in the human ectopic endometrial tissue. RESULT(S): Steroid receptors and estrogen-converting enzymes were expressed in the ectopic human endometrial fragments. Application of medroxyprogesterone acetate, dydrogesterone, danazol, and the aromatase inhibitor finrozole significantly inhibited aromatase transcription. In addition, danazol caused a significant decrease in transcription of steroid sulfatase, and finrozole, of 17beta-hydroxysteroid dehydrogenase type 1 in parallel to a decrease in proliferation rate in the ectopic human endometrial tissue. CONCLUSION(S): Pharmacological regulation of transcription of estrogen-converting enzymes in human endometrium cultured in nude mice may help to develop new therapeutic concepts based on local regulation of estrogen metabolism in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Choristoma Endometrium Estrogens Gene Expression Regulation, Enzymologic Animals Animals Choristoma Choristoma Choristoma Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Estrogens Estrogens Estrogens Female Female

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References (42)

Cited by (34)

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