HOX gene expression is altered in the endometrium of women with endometriosis

H S Taylor, Hugh S. Taylor, Bagot C, C Bagot, Kardana A, A Kardana, Olive D, D Olive, Arici A, A Arici
Human Reproduction · 1999 · vol. 14(5) , pp. 1328–1331 · doi:10.1093/humrep/14.5.1328 · PMID:10325287 · W2150404274
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Quantitative Northern blot analysis revealed that women with endometriosis exhibit altered HOX gene expression in their endometrium, lacking the expected mid-luteal rise observed in controls.

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Abstract

HOXA10 and HOXA11 are homeobox genes that function as transcription factors essential to embryonic development. We have recently described a role for each of these two genes in regulating endometrial development in the adult during the course of a menstrual cycle. Both Hoxa10 and Hoxa11 are essential for implantation in the mouse and appear to play a similar role in women. To investigate the role of HOX genes in the endometrium of women with endometriosis, quantitative Northern blot analysis was performed on the endometrium of 40 normal cycling controls and 40 patients with documented endometriosis. Patients with endometriosis failed to show the expected mid-luteal rise in HOX gene expression as demonstrated in the controls. Aberrant HOX gene expression suggests that altered development of the endometrium at the molecular level may contribute to the aetiology of infertility in patients with endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Embryo Implantation Embryo Implantation Endometriosis Endometrium Gene Expression Regulation, Developmental Genes, Homeobox Genes, Homeobox Transcription Factors Adult Adult Animals Animals Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometrium Endometrium Female Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

Cited by (50)

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