Genesis, genes and epigenetics of endometriosis-associated infertility
Loss of histone deacetylase 3 (HDAC3) in the endometrium is linked to hormonal imbalances, increased fibrosis, and impaired receptivity, contributing to endometriosis-associated infertility.
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This paper summarizes findings from research suggesting that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis and that loss of HDAC3 is linked to aberrant hormonal signaling, increased endometrial fibrosis, and impaired endometrial receptivity. The key reported outcome is that these changes associate with endometriosis-associated infertility through effects on uterine receptivity. A major limitation noted implicitly in a brief overview/commentary format is that it does not provide full experimental detail or quantify the strength of the associations within the text provided. This paper is centrally about endometriosis-associated infertility — specifically focusing on HDAC3, epigenetic regulation, and endometrial receptivity.
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References (11)
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Cited by (12)
- Metabolic Reprogramming Mediates Chronic Stress–Induced Immune Dysregulation in Endometriosis 2025
- Bushen Huoxue decoction improves the reproduction of endometriosis-associated infertility by regulating Homeobox A10 and αlpha(v)beta(3) integrin expression. 2024
- Chronic Stress Blocks the Endometriosis Immune Response by Metabolic Reprogramming 2023
- Peculiarities of the course of genital endometriosis and its recurrence in women of reproductive age 2023
- Persistent activation of signal transducer and activator of transcription 3 via interleukin-6 trans-signaling is involved in fibrosis of endometriosis 2022
- Genital endometriosis and fertility 2022
- Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2 2022
- Endometriosis and Subfertility: A Literature Review. 2022
- Peritoneal Modulators of EZH2-miR-155 Cross-Talk in Endometriosis 2021
- Immunoreactivity of Plasminogen Activator Inhibitor 1 and Its Correlation with Dysmenorrhea and Lesional Fibrosis in Adenomyosis 2021
- Impaired pathogen-induced autophagy and increased IL-1β and TNFα release in response to pathogenic triggers in secretory phase endometrial stromal cells of endometriosis patients 2020
- Identifying Mechanisms of Endometriosis-Associated Reduced Fecundity in a Rat Model: Novel Insights toward Understanding Human Infertility 2020
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