Genesis, genes and epigenetics of endometriosis-associated infertility

Guo SW, Sun-Wei Guo, Sun‐Wei Guo
Nature reviews. Endocrinology · 2019 · vol. 15(5) , pp. 259–260 · doi:10.1038/s41574-019-0191-9 · PMID:30886366 · W2921073589
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Downregulation of histone deacetylase 3 in the endometrium is associated with aberrant hormonal signaling, increased fibrosis, and impaired receptivity in women with endometriosis.

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This paper summarizes findings from research suggesting that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis and that loss of HDAC3 is linked to aberrant hormonal signaling, increased endometrial fibrosis, and impaired endometrial receptivity. The key reported outcome is that these changes associate with endometriosis-associated infertility through effects on uterine receptivity. A major limitation noted implicitly in a brief overview/commentary format is that it does not provide full experimental detail or quantify the strength of the associations within the text provided. This paper is centrally about endometriosis-associated infertility — specifically focusing on HDAC3, epigenetic regulation, and endometrial receptivity.

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References

Taylor, H. S. et al. HOX gene expression is altered in the endometrium of women with endometriosis. Hum. Reprod. 14, 1328–1331 (1999). Wu, Y. et al. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am. J. Obstet. Gynecol. 193, 371–380 (2005). Kim, J. J. et al. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol. Hum. Reprod. 13, 323–332 (2007). Kim, T. H. et al. Loss of HDAC3 results in nonreceptive endometrium and female infertility. Sci. Transl Med. 11, eaaf7533 (2019). Vinatier, D., Cosson, M. & Dufour, P. Is endometriosis an endometrial disease? Eur. J. Obstet. Gynecol. Reprod. Biol. 91, 113–125 (2000). Guo, S. W. Fibrogenesis resulting from cyclic bleeding: the holy grail of the natural history of ectopic endometrium. Hum. Reprod. 33, 353–356 (2018). Liu, X. et al. Transvaginal elastosonography as an imaging technique for diagnosing adenomyosis. Reprod. Sci. 25, 498–514 (2018). Markiewicz, M. et al. A role for estrogen receptor-alpha and estrogen receptor-beta in collagen biosynthesis in mouse skin. J. Invest. Dermatol. 133, 120–127 (2013). Oie, S. et al. HDAC3 regulates stability of estrogen receptor α mRNA. Biochem. Biophys. Res. Commun. 432, 236–241 (2013). Hoeksema, M. A. et al. Targeting macrophage histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol. Med. 6, 1124–1132 (2014).

Acknowledgements

The author acknowledges the support of grants 81530040 and 81771553 from the National Science Foundation of China and an Excellence in Centers of Clinical Medicine grant (2017ZZ01016) from the Science and Technology Commission of Shanghai Municipality. Author information Authors and Affiliations Corresponding author Ethics declarations Competing interests The author is an adjunct professor at the Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA. However, his affiliation at this university plays no part on the views expressed in this commentary. He has nothing else to declare. Rights and permissions About this article Cite this article Guo, SW. Genesis, genes and epigenetics of endometriosis-associated infertility. Nat Rev Endocrinol 15, 259–260 (2019). https://doi.org/10.1038/s41574-019-0191-9 Published: Version of record: Issue date: DOI: https://doi.org/10.1038/s41574-019-0191-9

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Endometriosis Endometrium Epigenesis, Genetic Female Humans Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

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