{"paper_id":"80b999e2-4225-49de-8cd8-62b80ea4a8be","body_text":"Jae-Wook Jeong and colleagues report that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis. In addition, they show that the loss of HDAC3 is associated with aberrant hormonal signalling and increased fibrosis in the endometrium and impaired endometrial receptivity.\nThis is a preview of subscription content, access via your institution\nAccess options\nAccess Nature and 54 other Nature Portfolio journals\nGet Nature+, our best-value online-access subscription\n27,99 € / 30 days\ncancel any time\nSubscribe to this journal\nReceive 12 print issues and online access\n176,64 € per year\nonly 14,72 € per issue\nRent or buy this article\nPrices vary by article type\nfrom$1.95\nto$39.95\nPrices may be subject to local taxes which are calculated during checkout\nReferences\nTaylor, H. S. et al. HOX gene expression is altered in the endometrium of women with endometriosis. Hum. Reprod. 14, 1328–1331 (1999).\nWu, Y. et al. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am. J. Obstet. Gynecol. 193, 371–380 (2005).\nKim, J. J. et al. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol. Hum. Reprod. 13, 323–332 (2007).\nKim, T. H. et al. Loss of HDAC3 results in nonreceptive endometrium and female infertility. Sci. Transl Med. 11, eaaf7533 (2019).\nVinatier, D., Cosson, M. & Dufour, P. Is endometriosis an endometrial disease? Eur. J. Obstet. Gynecol. Reprod. Biol. 91, 113–125 (2000).\nGuo, S. W. Fibrogenesis resulting from cyclic bleeding: the holy grail of the natural history of ectopic endometrium. Hum. Reprod. 33, 353–356 (2018).\nLiu, X. et al. Transvaginal elastosonography as an imaging technique for diagnosing adenomyosis. Reprod. Sci. 25, 498–514 (2018).\nMarkiewicz, M. et al. A role for estrogen receptor-alpha and estrogen receptor-beta in collagen biosynthesis in mouse skin. J. Invest. Dermatol. 133, 120–127 (2013).\nOie, S. et al. HDAC3 regulates stability of estrogen receptor α mRNA. Biochem. Biophys. Res. Commun. 432, 236–241 (2013).\nHoeksema, M. A. et al. Targeting macrophage histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol. Med. 6, 1124–1132 (2014).\nAcknowledgements\nThe author acknowledges the support of grants 81530040 and 81771553 from the National Science Foundation of China and an Excellence in Centers of Clinical Medicine grant (2017ZZ01016) from the Science and Technology Commission of Shanghai Municipality.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nCompeting interests\nThe author is an adjunct professor at the Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA. However, his affiliation at this university plays no part on the views expressed in this commentary. He has nothing else to declare.\nRights and permissions\nAbout this article\nCite this article\nGuo, SW. Genesis, genes and epigenetics of endometriosis-associated infertility. Nat Rev Endocrinol 15, 259–260 (2019). https://doi.org/10.1038/s41574-019-0191-9\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1038/s41574-019-0191-9","source_license":"CC0","license_restricted":false}