Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis

Shaohua Xu, Xu S, Wei Wu, Sun H, Hong Sun, Jing Lu, Jing Lü, Lu J, Yuan B, Beilei Yuan, Xia Y, Yankai Xia, Bart De Moor, De Moor B, Kathleen Marchal, Wang X, Xinru Wang, Xu P, Peizhen Xu, Wenjun Cheng, Cheng W
Annals of human genetics · 2012 · vol. 76(6) , pp. 464–471 · doi:10.1111/j.1469-1809.2012.00726.x · PMID:23061744 · W1871863160
Systematic review / meta-analysis OA: bronze CC0 ⤵ 12 in-corpus citations
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This meta-analysis of 11 studies found that the VEGF+936T/C polymorphism, but not -460C/T or +405G/C, is associated with increased endometriosis risk, particularly in stage III-IV.

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Abstract

Published data on the association between the vascular endothelial growth factor (VEGF) gene -460C/T (rs833061), +405G/C (rs2010963), +936T/C (rs3025039) polymorphisms and endometriosis risk are inconclusive. Eleven eligible case-control studies including 2690 cases and 2803 controls were included in this meta-analysis through searching the databases of PubMed and CBMdisc (up to August 1, 2011). In the overall analysis, no significant association between the -460C/T and +405G/C polymorphisms and risk of endometriosis was observed. However, significant associations were observed between endometriosis risk and VEGF+936T polymorphism with summarized odds ratio of 1.19 (95%CI, 1.02-1.37), 1.18 (95%CI, 1.03-1.37), 1.15 (95%CI, 1.01-1.30) for CT versus CC genotype, dominant mode (CT/TT vs. CC) and allele comparison (T vs. C), respectively. Furthermore, stratified analysis showed that significantly strong association between +936T/C polymorphism and endometriosis was present only in stage III-IV (OR = 1.32 for dominant mode; OR = 1.30 for T vs. C), but not in stage I-II. However, no significantly increased risk of endometriosis was found in any of the genetic models in Asians or in Caucasians. This meta-analysis supports that VEGF+936T/C polymorphism is capable of causing endometriosis susceptibility.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Vascular Endothelial Growth Factor A Endometriosis Endometriosis Female Female Humans Humans Odds Ratio Odds Ratio Publication Bias Publication Bias Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A

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