Effect of Wnt/β-catenin signal pathway on of matrix metalloproteinase-7 and vascular endothelial growth factor gene expressions in endometriosis

Xu H, Huiyong Xu, H Xu, Yang JJ, Jin Yang, J J Yang, C. H. Wang, Wang CH, E Y Guo, Erling Guo, Guo EY, N H Yang, N. Yang, Yang NH, Qiang Zhao, Zhao Q, Q Zhao
Clinical and experimental obstetrics & gynecology · 2016 · vol. 43(4) , pp. 573–577 · doi:10.12891/ceog3053.2016 · PMID:29734552 · W3000247997
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Blocking the Wnt/β-catenin signal pathway in an endometriosis model reduced matrix metalloproteinase-7 and vascular endothelial growth factor expression.

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This paper investigated how the Wnt/β-catenin signaling pathway influences endometriosis tissue adhesion, invasion, and metastasis by examining changes in β-catenin, matrix metalloproteinase-7 (MMP-7), and vascular endothelial growth factor (VEGF) expression. Using an endometriosis nude mouse model, the authors blocked Wnt/β-catenin signaling via small RNA interference and assessed lesion pathology (HE staining) alongside β-catenin, MMP-7, and VEGF at protein (immunohistochemistry) and mRNA (real-time quantitative PCR) levels. Blocking the pathway substantially reduced β-catenin, MMP-7, and VEGF in the siRNA group compared with negative controls, while pathological morphology differences were minimal and there was no significant expression difference between negative control and control groups. This paper is centrally about endometriosis — it tests how Wnt/β-catenin pathway blockade alters MMP-7 and VEGF expression in an endometriosis mouse model.

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Abstract

PURPOSE: To explore the function of Wnt/β-catenin signal pathway on promoting the adhesion, invasion, and metastasis of endometriosis tissues by analyzing its effects on the expressions of matrix metalloproteinase-7 (MMP-7) and vascular endothelial growth factor in en- dometriosis. MATERIALS AND METHODS: Endometriosis nude mice models were included. Small RNA interference technology was used to block Wnt/β-catenin signal pathway. HE staining technique was adopted to observe the difference of pathological morphology among groups. The immunohistochemistry and real-time quantitative PCR were perfonned to analyze the expressions of $-catenin, MMP-7 and VEGF from pro- tein and mRNA levels. RESULTS: Whether the Wnt/β-catenin signal pathway was blocked or not had little effect on the pathological mor- phology of lesions. The expressions of P-catenin, MMP-7 and VEGF in siRNA group were much lower than those in negative control group and control group (p 0.05). CONCLUSION: Blocking of Wnt/β-catenin signal pathway caused the decrease of MMP-7 and VEGF expressions, in- dicating that Wnt/β-catenin signal pathway plays an important role in the adhesion, invasion, and metastasis of endometriosis tissues.
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Effect of Wnt/β-catenin signal pathway on of matrix metalloproteinase-7 and vascular endothelial growth factor gene expressions in endometriosis H. Xu 1, J. J. Yang 2, C. H. Wang 2, E. Y. Guo 3, N. H. Yang 4, Q. Zhao 5,* 1 Department of Obstetrics and Gynecology, Zhengzhou People’s Hospital, Zhengzhou City 2 Department of Obstetrics and Gynecology, Women & Infants Hospital of Zhengzhou, Zhengzhou City 3 Department of Equipment, Zhengzhou People’s Hospital, Zhengzhou City 4 Department of Obstetrics and Gynecology, University Hospital of Hubei University For Nationalities, Enshi City 5 Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City (China) Published: 10 Aug 2016 The Author(s). Published by IMR Press. This is an open access article under the CC BY 4.0 license. Abstract Purpose: To explore the function of Wnt/β-catenin signal pathway on promoting the adhesion, invasion, and metastasis of endometriosis tissues by analyzing its effects on the expressions of matrix metalloproteinase-7 (MMP-7) and vascular endothelial growth factor in endometriosis. Materials and Methods: Endometriosis nude mice models were included. Small RNA interference technology was used to block Wnt/β-catenin signal pathway. HE staining technique was adopted to observe the difference of pathological morphology among groups. The immunohistochemistry and real-time quantitative PCR were performed to analyze the expressions of β-catenin, MMP-7 and VEGF from protein and mRNA levels. Results: Whether the Wnt/β-catenin signal pathway was blocked or not had little effect on the pathological morphology of lesions. The expressions of β-catenin, MMP-7 and VEGF in siRNA group were much lower than those in negative control group and control group (p 0.05). Conclusion: Blocking of Wnt/β-catenin signal pathway caused the decrease of MMP-7 and VEGF expressions, indicating that Wnt/β-catenin signal pathway plays an important role in the adhesion, invasion, and metastasis of endometriosis tissues.

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Condition tags

endometriosis

MeSH descriptors

beta Catenin Endometriosis Matrix Metalloproteinase 7 Vascular Endothelial Growth Factor A Wnt Signaling Pathway Animals beta Catenin Disease Models, Animal Endometriosis Endometriosis Female Gene Expression Immunohistochemistry Matrix Metalloproteinase 7 Matrix Metalloproteinase 9 Matrix Metalloproteinase 9 Mice Mice, Nude RNA, Messenger Vascular Endothelial Growth Factor A

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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