The development of endometriosis in a murine model is dependent on the presence of dendritic cells

Niv Pencovich, Pencovich N, Janelle Luk, Luk J, Hantisteanu S, Shay Hantisteanu, Mark D. Hornstein, Hornstein MD, Ofer Fainaru, Fainaru O
Reproductive BioMedicine Online · 2014 · vol. 28(4) , pp. 515–521 · doi:10.1016/j.rbmo.2013.12.011 · PMID:24581985 · W2061595920
Lab / animal OA: closed CC0 ⤵ 35 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-19 ⓘ

This study investigated the development of endometriosis in mice, finding it is dependent on the presence of dendritic cells.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a common condition associated with pelvic pain and infertility. This study group has previously shown that supplementation of dendritic cells led to enhancement of endometriosis lesion growth and angiogenesis. This study determined whether endometriosis is dependent on the presence of endogenous dendritic cells. Surgical induction of endometriosis was performed in CD11c⁺ DTR/GFP transgenic (Tg) female mice in which dendritic cells were ablated upon injection of diphtheria toxin (DT). Mice were allocated into four groups (n=5 each): group I, wild-type mice treated with vehicle; group II, wild-type mice treated with DT; group III, Tg mice treated with DT; and group IV, Tg mice treated with vehicle. After 10 days, mice were killed and endometriosis lesions were analysed by flow cytometry. DT treatment led to ablation of dendritic cells in spleens and endometriosis lesions in Tg mice while no ablation was observed in controls. Corresponding to dendritic cell ablation, endometriosis lesions in group III were ∼5-fold smaller than in the control groups (ANOVA P<0.0001). This study suggests that endometriosis development is dependent on the presence of endogenous dendritic cells. Therapies designed to inhibit dendritic cell infiltration as possible treatments for endometriosis warrant further study.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Dendritic Cells Endometriosis Animals Animals Dendritic Cells Dendritic Cells Diphtheria Toxin Diphtheria Toxin Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Female Female Mice, Inbred C57BL Mice, Inbred C57BL Mice, Transgenic Mice, Transgenic

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (38)

Cited by (36)

Source provenance

europepmc
last seen: 2026-10-20T06:13:28.455750+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:13:21.326790+00:00
unpaywall
last seen: 2026-10-20T06:27:24.728081+00:00
License: CC0 · commercial use OK