Today's treatments: medical, surgical and in partnership

Donnez J, Jacques Donnez, J. Donnez
International Journal of Gynecology & Obstetrics · 1999 · vol. 64(S1) , pp. 5–13 · doi:10.1016/s0020-7292(98)00236-7 · PMID:10096459 · W2059861419
Review OA: closed CC0 ⤵ 10 in-corpus citations
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Medical treatments like GnRH agonists and surgical interventions both alleviate endometriosis pain and reduce implants, though recurrence and side effects remain concerns for all approaches.

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Abstract

OBJECTIVE: To provide an overview of the medical, surgical and combined therapy options for endometriosis. RESULTS: Available medical options include danazol, progestogens, gestrinone, oral contraceptive agents, analgesics and gonadotropin-releasing hormone (GnRH) agonists. Used in the short-term, most of these agents relieve pain in a large proportion of patients and produce disease regression, however, they do not prevent recurrence, and are associated with side-effects. However, few data confirm any benefit of short-term medical therapy on fertility. One of the most promising medical approaches appears to be GnRH agonists with add-back hormone replacement therapy. Surgery may relieve pain, eradicate visible disease and improve fertility. A combined approach may facilitate surgery and relieve pain, although any fertility benefit is as yet unproven. CONCLUSION: Both short-term medical treatment and surgery relieve endometriosis-associated pain and decrease endometriotic implants. However, all approaches have side effects which must be balanced against the benefits when defining suitable treatment for a particular patient.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Gynecologic Surgical Procedures Gynecologic Surgical Procedures Humans Humans Laparoscopy Laparoscopy

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (60)

Cited by (10)

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