Endocrine effects of danazol in the treatment of endometriosis

J. R. Bevan, Bevan JR, M Dowsett, Mitch Dowsett, Dowsett M, Jeffcoate SL, S L Jeffcoate
British journal of obstetrics and gynaecology · 1984 · vol. 91(2) , pp. 160–166 · doi:10.1111/j.1471-0528.1984.tb05901.x · PMID:6538094 · W2032898200
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Danazol therapy for endometriosis caused a significant rise in LH, a fall in estradiol, and a marked decrease in SHBG, suggesting its effects may stem from SHBG modulation rather than an anti-gonadotropic action.

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Abstract

The effects of danazol therapy on circulating gonadotrophins, oestradiol and sex hormone-binding globulin (SHBG) binding capacity have been studied in eight patients with endometriosis. There was a significant rise in luteinizing hormone (LH) in the first week of treatment with a fall in oestradiol levels. There was a marked fall in SHBG in the first week which continued up to 4 weeks. It is concluded that danazol is not 'anti-gonadotrophic' as frequently claimed and that its therapeutic actions, side effects and the endocrine changes could be explained by an effect on SHBG production. The rationale of its use in other conditions requires reconsideration.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Estradiol Gonadotropins, Pituitary Pelvic Neoplasms Pregnadienes Adult Adult Danazol Danazol Endometriosis Endometriosis Endometriosis Estradiol Estradiol Female Female Gonadotropins, Pituitary Gonadotropins, Pituitary Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (36)

Cited by (15)

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