Antagonism of amignoglutethimide and danazol in the suppression of serum free oestradiol in breast cancer patients

Mitch Dowsett; Richard Murray; Paula Pitt; S.L. Jeffcoate

doi:10.1016/0277-5379(85)90292-5

Antagonism of amignoglutethimide and danazol in the suppression of serum free oestradiol in breast cancer patients

Mitch Dowsett, Richard Murray, Paula Pitt, S.L. Jeffcoate

In: European Journal of Cancer and Clinical Oncology · 1985 · vol. 21(9) , pp. 1063–1068 · doi:10.1016/0277-5379(85)90292-5 · PMID:4065179 · W2053378295

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This study investigated the effectiveness of amignoglutethimide and danazol in suppressing serum free estradiol levels in breast cancer patients.

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Abstract

The response rate of advanced postmenopausal breast cancer patients to treatment with aminoglutethimide (AG) + danazol was significantly worse than that with AG alone. The suppression of serum oestradiol levels by AG + danazol was similar to that by AG alone, but the combination treatment also suppressed sex hormone binding globulin (SHBG) levels and increased the % free oestradiol, whilst these parameters were unaffected by AG alone. The degree of suppression by AG + danazol of free oestradiol concentrations was less than the suppression of total oestradiol level and in some patients the concentration of the free fraction was increased above pretreatment levels. These effects on the presumed biologically active unbound fraction of oestradiol may explain the poor clinical response rate to AG + danazol.

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Danazol 2022

References (26)

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Endocrine effects of danazol in the treatment of endometriosis via openalex
Tamoxifen, aminoglutethimide and danazol: effect of therapy on hormones in post-menopausal patients with breast cancer via openalex
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Cited by (1)

Danazol 2022

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[1] Endocrine effects of danazol in the treatment of endometriosis 1984

[2] Danazol treatment for advanced breast cancer 1983

[3] Tamoxifen, aminoglutethimide and danazol: effect of therapy on hormones in post-menopausal patients with breast cancer 1982

[4] TREATMENT OF DISSEMINATED BREAST CANCER WITH TAMOXIFEN, AMINOGLUTETHIMIDE, HYDROCORTISONE, AND DANAZOL, USED IN COMBINATION OR SEQUENTIALLY 1984