Florid polypoid endometriosis exacerbated by tamoxifen therapy in breast cancer
Case report
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⤵ 22 in-corpus citations
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This case report describes a premenopausal breast cancer patient whose tamoxifen therapy appeared to exacerbate florid polypoid endometriosis, suggesting hormonal therapy may need careful consideration in patients with pre-existing endometriosis.
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Abstract
BACKGROUND: We report an unusual case where tamoxifen may have exacerbated the growth of multiple polypoid endometriotic implants.
CASE: A premenopausal woman with right breast intraductal carcinoma underwent modified radical mastectomy and received six courses of chemotherapy, followed by continuous oral tamoxifen. Irregular vaginal bleeding was noted 5 years after the mastectomy and transvaginal ultrasound detected a 6-cm cul-de-sac mass. The serum CA 125 level was 138.86 U/mL. Surgical pathology showed florid polypoid endometriosis over the resected rectal segment and endometriotic implants over multiple biopsy sites of the peritoneal surface.
CONCLUSION: The estrogenic effects of tamoxifen may have induced florid endometriosis in this hypoestrogenic woman. If breast cancer patients have preexisting endometriosis, adjuvant hormonal therapy other than tamoxifen should be considered.
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References (8)
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- Role of cytokines in endometriosis via openalex
- Tamoxifen treatment and gynecologic side effects: a review via openalex
- Treating endometriosis as an autoimmune disease via openalex
- W2134551047 via openalex
- W1974993766 via openalex
- W92359167 via openalex
Cited by (22)
- Rapidly growing extensive polypoid endometriosis after gonadotropin-releasing hormone agonist discontinuation: A case report 2023
- Polypoid endometriosis mimicking malignancy: a clinicopathological analysis of 28 cases and literature review 2023
- A case of polypoid endometriosis mimicking advanced ovarian carcinoma with rapid growth, invasion, and dissemination 2022
- MR findings of polypoid endometriosis of female genital organs: report of three cases 2022
- Fertility preservation of polypoid endometriosis: Case series and literature review 2021
- Polypoid endometriosis: a mimic of malignancy 2019
- Polypoid endometriosis in a young woman: a case report and review of literature 2019
- Polypoid endometriosis mimicking invasive cancer in an obese, postmenopausal tamoxifen user 2017
- A case of ureteric polypoid endometriosis presenting in a post-menopausal woman 2017
- Selected Case From the Arkadi M. Rywlin International Pathology Slide Club: Polypoid Endometriosis in the Pouch of Douglas in a Perimenopausal Woman 2015
- Multifocal Polypoid Endometriosis Mimicking Malignancy in a Young Woman with a History of Hormonal Treatment 2015
- Huge polypoid endometriosis: report of a case and review of the literature 2015
- Clinicopathological and immunohistological features of polypoid endometriosis 2015
- Polypoid Endometriosis of the Cervix Mimicking a Uterine Malformation: Case Report 2013
- Polypoid Endometriosis Suspected preoperatively and Resolved by a Laparoscopic Hysterectomy: Case Report 2013
- Vaginal polypoid endometriosis simulating neoplasia in a young woman 2012
- Multifocal polypoid endometriosis in a young woman simulating vaginal and pelvic neoplasm 2010
- Endometriosis as a model for inflammation-hormone interactions in ovarian and breast cancers 2006
- Endometriosis: harmful survival of an ectopic tissue 2006
- Benign Gynecological Diseases and SERMs 2006
- Polypoid endometriosis and other benign gynaecological complications associated with Tamoxifen therapy-a case to illustrate features on magnetic resonance imaging 2006
- Pathology of endometriosis 1990
Source provenance
- europepmc
- last seen: 2026-10-12T06:17:10.165071+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:02:12.072533+00:00
- unpaywall
- last seen: 2026-10-12T06:33:14.382917+00:00
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