Safety and efficacy of high intensity focused ultrasound ablation therapy for adenomyosis

Wang W, Wei Wang, Wang Y, Yuexiang Wang, Jie Tang, Tang J
Academic radiology · 2009 · vol. 16(11) , pp. 1416–1423 · doi:10.1016/j.acra.2009.06.005 · PMID:19683943 · W2089868719
Non-randomised trial OA: closed CC0 ⤵ 37 in-corpus citations
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This study investigated the safety and efficacy of high intensity focused ultrasound (HIFU) ablation therapy for adenomyosis, assessing treatment outcomes and patient well-being.

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Abstract

RATIONALE AND OBJECTIVES: In patients with adenomyosis, the severity of symptoms correlates roughly with the extent of adenomyosis. Thus, it was hypothesized that the ablation of enough volume of adenomyosis might alleviate symptoms. The aim of this study was to investigate the safety and efficacy of high-intensity focused ultrasound (HIFU) ablation for the treatment of adenomyosis. MATERIALS AND METHODS: Phase I HIFU ablation of adenomyosis was performed on 12 patients. Three patients each were treated using four different acoustic intensities (290, 340, 380, and 420 W) step by step. Contrast-enhanced ultrasound was used to evaluate the necrotic region of treated adenomyosis. The efficacy of therapy was evaluated after 3 months of follow-up. RESULTS: All patients in the four groups tolerated the therapy well, and no severe complications were found during follow-up. After treatment, nonenhanced necrotic regions were shown on contrast-enhanced ultrasound in all treated adenomyosis. The mean volumes of the nonenhanced regions were 72, 75, 68, and 124 cm(3) in the 290-W, 340-W, 380-W, and 420-W groups, respectively. At 3 months after therapy, the mean pain relief in the four groups was 25%, 58.3%, 66.7%, and 83.3%, respectively. CONCLUSIONS: HIFU may be a safe and effective method to treat adenomyosis, and an acoustic intensity of 420 W may be able to produce larger volumes of necrosis and better pain relief.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Endometriosis High-Intensity Focused Ultrasound Ablation Adult Adult Endometriosis Endometriosis Female Female High-Intensity Focused Ultrasound Ablation High-Intensity Focused Ultrasound Ablation Humans Humans Male Male Middle Aged Middle Aged Treatment Outcome Treatment Outcome Ultrasonography

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (36)

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