Metabolomics Reveals Altered Lipid Metabolism in a Mouse Model of Endometriosis

Mainak Dutta, Anitha M, Mallappa Anitha, Smith PB, Philip B. Smith, Christopher Chiaro, Christopher R Chiaro, Chiaro CR, Maan M, Meenu Maan, Koel Chaudhury, Andrew D. Patterson
Journal of proteome research · 2016 · vol. 15(8) , pp. 2626–2633 · doi:10.1021/acs.jproteome.6b00197 · PMID:27246581 · W2435714804
Lab / animal OA: closed CC0 ⤵ 32 in-corpus citations
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This lipidomics study identified dysregulated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, and triglycerides in mouse serum, with triglyceride elevation possibly linked to inflammation and altered phosphatidylcholine/phosphatidylethanolamine ratios potentially tied to gene expression changes.

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Abstract

Endometriosis is a common chronic estrogen-dependent gynecological disease affecting 10% of women in their reproductive age. It is characterized by proliferation of functional endometrial glands and stroma outside the uterine cavity. In the present study, we used mass spectrometry-based lipidomics to investigate the alterations in serum lipid profiles of mice induced with endometriosis. We identified several dysregulated lipids such as phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, and triglycerides and show that triglycerides may be due to a general inflammatory condition in the peritoneum. We also show that in addition to phosphatidylcholine alteration, there is also an effect in the ratio of phosphatidylcholine/phosphatidylethanolamine in serum of mice induced with the disease and that this change may be due to increased expression of the phosphatidylethanolamine N-methyltransferase gene. The study provides new insight into the etiology of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Lipid Metabolism Lipid Metabolism Metabolomics Metabolomics Animals Animals Endometriosis Endometriosis Endometriosis Female Female Mice Mice Phosphatidylcholines Phosphatidylcholines Phosphatidylcholines Phosphatidylcholines Phosphatidylethanolamines Phosphatidylethanolamines

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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