Alterations in lipid metabolism in ovarian endometriosis and combined ovarian cancer revealed by untargeted lipidomics

YuHan DUAN, HeLin WANG, Kun ZHANG
2025 · doi:10.1360/ssv-2024-0352 · W7083673460
article OA: bronze CC0
📄 Open PDF Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Untargeted lipidomics revealed distinct lipid metabolism differences in serum and urine between ovarian endometriosis, benign ovarian tumors, and ovarian cancer, suggesting a role for lipid metabolism in endometriosis and its progression to cancer.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The paper investigates lipid-metabolism alterations in ovarian endometriosis and in combined ovarian cancer using untargeted lipidomics, analyzing lipid profiles across relevant ovarian disease samples. The authors report that lipidomic profiles differ between conditions, revealing distinct alterations associated with ovarian endometriosis and with combined ovarian cancer. A major limitation is that the provided text does not include the study’s detailed design, sample size, or explicit caveats, so these aspects cannot be assessed from the excerpt. This paper is centrally about endometriosis — it specifically characterizes ovarian endometriosis–associated lipid metabolism changes revealed by untargeted lipidomics.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

目的：分析比较卵巢子宫内膜异位症（ovarian endometriosis，OEMs）与卵巢良性肿瘤（benign ovarian tumor，BOT）和OEMs合并卵巢癌（Ovarian cancer，OC）患者血清及尿液中脂质代谢产物的差异及相关代谢途径，初步探究与OEMs发生及其恶化相关的脂质成分，进一步深入了解EMs的发生发展机制。 方法：选择10名患有OEMs(对照组)、10名患有BOT（BOT组）和10名患有OEMs合并卵巢癌（恶性组）的育龄期妇女的血清及尿液样本。采用非靶向超高效液相色谱-质谱（UPLC-LC-MS）分析各组样本差异脂质代谢产物，通过多变量偏最小二乘判别分析（partial least squares discriminant analysis，PLS-DA）模型分析前两个主成分的计算变量投影重要度（Variable Important for the Projection，VIP）值，结合单变量分析变异倍数分析（Fold change）和 T 检验（p-value）值来筛选差异表达的代谢物，进一步通过KEGG注释筛选相关代谢途径。 结果：经单变量与多变量联合统计分析，BOT组与对照组血清及尿液样本进行检测，两组研究对象血清及尿液脂质代谢物均存在显著差异，其中血清中有13种显著不同的脂质代谢物，尿液中有9种。KEGG结果注释分析显示花生四烯酸代途径在血清及尿液中均富集，自噬途径在血清样本中富集。恶性组与对照组血清及尿液脂质代谢物均存在显著差异，其中血清中有81种显著不同的脂质代谢物，尿液中有6种，血清和尿液样本均存在显著差异的脂质代谢物为主要有甘油磷脂酸（phosphatidic acid，PA）和磷脂酰胆碱（Phosphatidyl cholines，PC）。KEGG结果注释分析显示亚油酸代谢途径在血清及尿液中均富集，而血清样本中还揭示了鞘脂信号通路、花生四烯酸代谢途径的富集。 结论：本次OEMs合并卵巢癌患者及BOT患者相比单纯OEMs患者血清及尿液脂质代谢物表达均存在差异，提示了OEMs的发生及合并卵巢癌与脂质代谢可能有关。
Full text 1,545 characters · extracted from oa-doi-fallback · click to expand
× SciEngine Journals & Books JOURNALS BOOKS CART CUSTOMER 中文 LOGIN Search SciEngine AI Intelligent Search Advanced Search LOG IN TO SciEngine Account Login Get verification code Forget the password Get code Sign in Register reset password Reset password link has been sent to your mailbox. Please check it in the mailbox. Print ISSN : 1674-7232 Online ISSN : 2095-9443 CN : 11-5840/Q Free Content Menus Advanced Search Home Browse Latest Issue All Issues Cover Stories Author Center Requirements for Submission Manuscript format Template Author Services Editorial Board Editorial Board(2023-2027) Editorial board(2018-2022) About Journal overview Editorial Staff Article types Open Access Open Access Statement Licensing Policy Copyright Statement Online Access and Archiving Peer Review Policy News Home Browse Latest Issue All Issues Cover Stories Author Center Requirements for Submission Manuscript format Template Author Services Editorial Board Editorial Board(2023-2027) Editorial board(2018-2022) About Journal overview Editorial Staff Article types Open Access Open Access Statement Licensing Policy Copyright Statement Online Access and Archiving Peer Review Policy News Advanced Search × Add new Menu Name English Chinese URL Sort Jump Way _self _blank × Update Menu Name English Chinese URL Sort Jump Way _self _blank BACK TO TOP TOP × Company Info Chinese Company Info Integrated Info Register System Info Waiting... Interesting search NetworkPositioning Search results View all results from this journal/book Top 5 Related Articles

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Source provenance

openalex
last seen: 2026-05-14T06:37:42.479783+00:00
License: CC0 · commercial use OK