The role of tissue factor and protease-activated receptor 2 in endometriosis

Lin M, Min Lin, Huinan Weng, Weng H, Wang X, Xuefeng Wang, Zhou B, Bing Zhou, Ping Yü, Ping Yu, Yu P, Yifeng Wang, Wang Y
American journal of reproductive immunology (New York, N.Y. : 1989) · 2012 · vol. 68(3) , pp. 251–257 · doi:10.1111/j.1600-0897.2012.01152.x · PMID:22672593 · W2084600050
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Tissue factor and protease-activated receptor 2 expression are upregulated in eutopic and ectopic endometrium of women with endometriosis, suggesting a role in lesion development.

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Abstract

PROBLEM: Little is known about the roles of TF and PAR-2 in endometriosis. This article investigated the expression of TF and PAR-2 in ectopic and eutopic endometrium with endometriosis and their relationship with the menstrual cycle. METHODS: Ectopic and eutopic endometrium tissues from 42 women with ovarian endometrioma and endometrium tissues from 20 women without endometriosis were obtained. All the samples were assessed for TF and PAR-2 protein location using immunohistochemistry and for relative TF and PAR-2 mRNA expression using real-time florescent quantitative polymerase chain reaction (FQ-PCR). RESULTS: Total TF and PAR-2 expression were significantly higher in ectopic and eutopic endometrium of women with endometriosis when compared with controls. Moreover, TF expression in ectopic and eutopic endometrium and PAR-2 expression in ectopic endometrium were significantly increased through the whole menstrual cycle. However, in eutopic endometrium with endometriosis, PAR-2 expression only in secretory phase was higher than its cycle-matched normal controls. There is no such difference in the proliferative phase. CONCLUSION: The abnormal co-upregulated expression of TF and PAR-2 in eutopic and ectopic endometrium may affect the development and growth of endometriotic lesions and highlighted the pathologic role of TF and PAR-2 in eutopic endometrium in endometriosis.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometrium Receptor, PAR-2 Thromboplastin Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Gene Expression Gene Expression Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (17)

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