Diagnostic value of serum CA125, CA19-9 and CA15-3 in endometriosis: A meta-analysis

Airong Shen, Shen A, Shengnan Xu, Xu S, Ma Y, Yange Ma, Huanhuan Guo, Guo H, Canyu Li, Li C, Yang C, Chunli Yang, Shunhong Zou, Zou S
The Journal of international medical research · 2015 · vol. 43(5) , pp. 599–609 · doi:10.1177/0300060515583076 · PMID:26246541 · W1943484987
Systematic review / meta-analysis OA: gold CC0 ⤵ 32 in-corpus citations
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This meta-analysis of 12 studies found that serum CA125 and CA19-9 concentrations are associated with endometriosis, suggesting their utility as noninvasive diagnostic biomarkers.

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Abstract

AIM: To evaluate the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis. METHODS: Case-control studies evaluating CA125, CA19-9 and CA15-3 and endometriosis, published between January 2000 and November 2014 were retrieved from PubMed(®) and Google Scholar. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated. Subgroup analyses were carried out by ethnicity and disease stage (early, stage I/II; advanced, stage III/IV). RESULTS: The analysis included 12 case-control studies (963 cases, 855 controls). CA125 was associated with endometriosis in the overall population (SMD 0.82, 95% CI 0.72, 0.92), Caucasian subgroup (SMD 1.08, 95% CI 0.96, 1.19), and early (SMD 1.20, 95% CI 0.93, 1.48) or advanced disease (SMD 1.29, 95% CI 1.04, 1.55). CA19-9 was associated with endometriosis in the overall population (SMD 0.48, 95% CI 0.24, 0.72), Caucasian subgroup (SMD 0.31, 95% CI 0.07, 0.55), Asian subgroup (SMD 9.65, 95% CI 7.88, 11.42) and advanced disease (SMD 0.60, 95% CI 0.34, 0.87). CA15-3 was significantly associated with advanced disease (SMD 0.47, 95% CI 0.09, 0.84). CONCLUSIONS: Serum CA125 and CA19-9 may represent useful biomarkers for the noninvasive diagnosis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

CA-125 Antigen CA-19-9 Antigen Endometriosis Mucin-1 Asian People Asian People CA-125 Antigen CA-125 Antigen CA-19-9 Antigen CA-19-9 Antigen Endometriosis Endometriosis Endometriosis Female Female Humans Humans Mucin-1 Mucin-1 White People

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

Cited by (36)

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