Serum levels of the oncofetal antigens CA-125, CA 19-9 and CA 15-3 in patients with endometriosis

Dimitrios Panidis, D Panidis, G Vlassis, J Matalliotakis, J. M. Matalliotakis, S Skiadopoulos, Spyros Skiadopoulos, A Kalogeropoulos, Andreas P. Kalogeropoulos
Journal of endocrinological investigation · 1988 · vol. 11(11) , pp. 801–804 · doi:10.1007/bf03350229 · PMID:3225401 · W1978141139
article OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study measured CA-125, CA 19-9, and CA 15-3 serum levels in endometriosis patients before, during, and after danazol treatment, finding pretreatment elevation and significant reduction post-treatment.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper measured serum oncofetal antigens CA-125, CA 19-9, and CA 15-3 in 8 women with endometriosis (ages 21–37), assessing levels before treatment, during the last 15 days of a 6-month danazol regimen, and again 3 months after stopping danazol. Before treatment, some participants had elevated levels across all three markers or only subsets, and danazol significantly reduced CA-125 and CA-19-9 (and to a lesser degree CA 15-3), with levels remaining significantly lower 3 months post-therapy. The authors conclude that endometriosis is among pathological conditions associated with elevated levels of these antigens and that ovarian function mainly influences CA-125 and CA 19-9, while the study’s small sample size is a major caveat. This paper is centrally about endometriosis — it characterizes how danazol affects CA-125, CA 19-9, and CA 15-3 serum levels in women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Endometriosis Adult Antigens, Tumor-Associated, Carbohydrate Danazol Danazol Endometriosis Endometriosis Female Humans

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Cited by (11)

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