Social psychogenic stress promotes the development of endometriosis in mouse

Sun-Wei Guo, Sun‐Wei Guo, Qi Zhang, Zhang Q, Liu X, Xishi Liu
Reproductive BioMedicine Online · 2016 · vol. 34(3) , pp. 225–239 · doi:10.1016/j.rbmo.2016.11.012 · PMID:28038848 · W2561434375
Lab / animal OA: closed CC0 ⤵ 30 in-corpus citations
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This study investigated how social psychogenic stress impacts endometriosis development in mice, observing its promotion of the condition.

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Abstract

Exposure to chronic stress before and well after the induction of endometriosis is reported to increase lesion sizes in rats, but it is unclear whether stress, exposed shortly after the induction of endometriosis, would also promote the development of endometriosis, nor is it clear what the underlying possible molecular mechanism is. This study was undertaken to test the hypothesis that chronic stress can promote the development of endometriosis. A prospective randomized mouse experiment was conducted that subjected mice with induced endometriosis to predator stress. In addition, a cross-sectional immunohistochemistry study was performed in ectopic and eutopic endometrial tissue samples from age- and roughly menstrual phase-matched women with ovarian endometriomas. It was found that the chronic psychogenic stress induced epigenetic changes in the hippocampus in mouse independent of endometriosis. It was also found that chronic psychogenic stress induced epigenetic changes in the hippocampus of mice with endometriosis, and seemingly activated the adrenergic signalling in ectopic endometrium, resulting in increased angiogenesis and accelerated growth of endometriotic lesions. Thus, chronic psychogenic stress promotes endometriosis development, raising the possibility that the use of anti-depressants in cases of prolonged and intense stress might forestall the negative impact of stress on the development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Stress, Psychological Animals Animals Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Epigenesis, Genetic Epigenesis, Genetic Female Female Humans Humans Mice Mice Mice, Inbred C57BL

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (83)

Cited by (30)

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