Localization of anti-endometrial antibody binding in women with endometriosis using a double-labelling immunohistochemical method

Kennedy SH, Stephen Kennedy, S H Kennedy, I L Sargent, Ian L. Sargent, Sargent IL, P M Starkey, Starkey PM, B R Hicks, Hicks BR, David H. Barlow, D H Barlow, Barlow DH
British journal of obstetrics and gynaecology · 1990 · vol. 97(8) , pp. 671–674 · doi:10.1111/j.1471-0528.1990.tb16236.x · PMID:2400746 · W1964479501
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A double-labeling immunohistochemical method localized anti-endometrial antibodies to glandular epithelium cytoplasm, finding them in significantly more women with endometriosis (14/40) than controls (1/40).

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Abstract

Anti-endometrial antibody binding was localized using a double-labelling immunohistochemical method on frozen sections of endometrium taken from a woman without pelvic disease. Serum from 40 women with endometriosis was tested and, as controls, serum samples from 20 adult males and 20 umbilical cords. The method allowed compensation for endogenous immunoglobulins in endometrium and accurate localization of anti-endometrial antibody binding in the cytoplasm of the glandular epithelium. Significantly more women with endometriosis (14/40) were found to have anti-endometrial antibodies than controls (1/40) (P less than 0.001; chi 2). There was no correlation between disease severity and the presence of anti-endometrial antibodies or the intensity of staining.

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Condition tags

endometriosis

MeSH descriptors

Antibodies, Neoplasm Endometriosis Endometrium Ovarian Neoplasms Adult Adult Antibodies, Neoplasm Antibodies, Neoplasm Antibodies, Neoplasm Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Immunohistochemistry Immunohistochemistry

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (25)

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