Association of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism with advanced-stage endometriosis

Hwang KR, Kyu Ri Hwang, Choi YM, Young Min Choi, Jong Mee Kim, Kim JM, Gyoung Hoon Lee, Lee GH, Jin Ju Kim, Kim JJ, Jinju Kim, Soo Jin Chae, Shin Yong Moon, Moon SY
American journal of reproductive immunology (New York, N.Y. : 1989) · 2010 · vol. 64(5) , pp. 333–338 · doi:10.1111/j.1600-0897.2010.00882.x · PMID:20560917 · W2103492138
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The PPAR-γ2 Pro12Ala polymorphism was found to be associated with advanced-stage endometriosis in a Korean population, with the Ala-12 allele potentially offering protective effects.

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Abstract

PROBLEM: To investigate whether the peroxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala polymorphism is associated with a risk of advanced-stage endometriosis in a Korean population. METHODS OF STUDY: Case-control study in a collective of 446 patients and 427 controls. The Pro12Ala polymorphism of PPAR-γ2 gene was genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The distribution of the PPAR-γ2 Pro12Ala polymorphism was different between the advanced-stage endometriosis group and the control group (non-CC rates were 5.2% for patients with advanced endometriosis and 10.1% for the control group, respectively, P = 0.006). The frequency for the Ala-12 allele variant was significantly lower in patients with advanced stage of endometriosis (2.7%) than in the control group (5.3%) (P = 0.006). CONCLUSION: These findings suggest that the PPAR-γ2 Pro12Ala polymorphism is associated with advanced-stage endometriosis in the Korean population. Unlike results from other studies reported so far, the Ala-12 allele may have protective effects against advanced-stage endometriosis in the Korean population.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis PPAR gamma Alleles Alleles Case-Control Studies Case-Control Studies Chi-Square Distribution Chi-Square Distribution DNA DNA DNA DNA Endometriosis Endometriosis Endometriosis Female Female Genetic Variation Genetic Variation Humans

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