Expression of integrin adhesion molecules in endometrium and endometriosis

J E Bridges, Jackie Bridges, Bridges JE, Andrew Prentice, A Prentice, Prentice A, W. R. Roche, Roche W, W Roche, Englefield P, P. Englefield, Thomas EJ, E J Thomas, Eric J. Thomas
British journal of obstetrics and gynaecology · 1994 · vol. 101(8) , pp. 696–700 · doi:10.1111/j.1471-0528.1994.tb13187.x · PMID:7947505 · W1995909293
Other OA: closed CC0 ⤵ 38 in-corpus citations
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This study compared integrin expression in eutopic and ectopic endometrium from patients with endometriosis, finding differences between endometrial stages but no difference between eutopic and ectopic tissue.

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Abstract

OBJECTIVE: To compare the expression of cell adhesion molecules by endometrium and endometriosis. DESIGN: A comparative study of integrin expression, determined immunohistochemically, in eutopic and ectopic endometrium biopsied synchronously from patients with endometriosis diagnosed at laparoscopy or laparotomy. SETTING: University Departments of Obstetrics and Gynaecology, and Pathology, Southampton; Department of Obstetrics and Gynaecology, Newcastle upon Tyne. SAMPLES: Eighteen paired samples of endometria and endometriosis. RESULTS: A wide distribution of collagen-laminin receptor proteins was demonstrated. alpha 1 integrin expression was limited to secretory endometrium. beta 3 expression was only demonstrated on proliferative endometrium. CONCLUSIONS: Expressions of the integrin proteins differed between the various elements of the endometrium. Cyclical changes in integrin expression also were demonstrated. No difference in cell adhesion molecule expression was seen when comparing endometrial and endometriosis samples.

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Condition tags

endometriosis

MeSH descriptors

Cell Adhesion Molecules Endometriosis Endometrium Cell Adhesion Molecules Cell Adhesion Molecules Endometriosis Endometriosis Endometrium Endometrium Endothelium, Vascular Endothelium, Vascular Endothelium, Vascular Female Female Humans Humans Immunohistochemistry Immunohistochemistry Integrins Integrins

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

Cited by (38)

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