De novo formation of adhesions in endometriosis: the role of iron and free radical reactions

Arumugam K, K. Arumugam, Kulenthran Arumugam, Y C Yip, Yim Chee Yip, Yip YC
Fertility and sterility · 1995 · vol. 64(1) , pp. 62–64 · doi:10.1016/s0015-0282(16)57655-9 · PMID:7789581 · W2406857956
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This paper investigates the de novo formation of adhesions in endometriosis, focusing on the involvement of iron and free radical reactions.

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Abstract

OBJECTIVE: To show that raised iron levels in the peritoneal fluid (PF) of patients with endometriosis catalyze free radical reactions that results in the tissue destruction and fibrosis seen in these patients. DESIGN: A case-controlled study of the iron levels (microgram/mL) in the pelvic PF of 12 patients with moderate-to-severe disease, 15 patients with minimal-to-mild disease and in 17 women with normal pelvises were compared. As an index of free radical reactions through lipid peroxidation, the levels of malondialdehyde levels (ng/mL) were assessed simultaneously in the same specimens. RESULTS: Controlling for the phase of the menstrual cycle, significantly higher levels of iron were seen in patients with endometriosis, the levels being correlated with the severity of the disease. However no such corresponding relationship was seen in the malondialdehyde levels in the PF. CONCLUSIONS: These results suggest that raised iron levels in the PF do not play a role in catalyzing free radical reactions as judged by the degree of lipid peroxidation.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endometriosis Iron Malondialdehyde Tissue Adhesions Ascitic Fluid Ascitic Fluid Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Free Radicals Free Radicals Humans Humans Iron Iron

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

Cited by (50)

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