Peritoneal fluid and serum autoantibody levels in patients with endometriosis

Confino E, E Confino, Edmond Confino, Harlow L, L Harlow, Lisa A. Harlow, Norbert Gleicher, Gleicher N, N Gleicher
Fertility and sterility · 1990 · vol. 53(2) , pp. 242–245 · doi:10.1016/s0015-0282(16)53274-9 · PMID:2298309 · W2410234564
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This study measured peritoneal fluid and serum autoantibody levels in patients with endometriosis to identify potential diagnostic biomarkers.

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Abstract

Patients with endometriosis demonstrate autoantibody abnormalities in their peripheral blood. Whether such abnormalities can also be detected in the peritoneal cavity, has not been established. We therefore investigated autoantibodies to 6 phospholipid antigens, 5 histones and histone subfractions and 4 polynucleotides in 14 laparoscopically diagnosed endometriosis and 9 control patients, undergoing laparoscopic tubal occlusion, in both serum and peritoneal fluid. Endometriosis patients demonstrated significantly lower total immunoglobulin G (IgG) levels in peritoneal fluid than controls. In contrast, specific IgG autoantibody levels were higher in peritoneal fluids of endometriosis patients. Mean antiphospholipids and antihistones autoantibodies reached significance when serum/peritoneal fluid ratios were compared with controls. Significant differences between endometriosis and control patients were restricted to IgG isotypes and were not observed for either IgM or IgA isotypes. These data suggest an abnormal concentration of IgG antiphospholipids and antihistones antibodies within the peritoneal cavity of endometriosis patients, which may play a contributing role in the peritoneal pathology of this condition.

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Condition tags

endometriosis

MeSH descriptors

Autoantibodies Endometriosis Peritoneal Cavity Autoantibodies Autoantibodies Endometriosis Endometriosis Endometriosis Endometriosis Female Female Histones Histones Histones Humans Humans Immunoglobulin A Immunoglobulin A Immunoglobulin A Immunoglobulin G

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (36)

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