A pilot study on the off-label use of valproic acid to treat adenomyosis

Liu X, Xishi Liu, Guo SW, Sun-Wei Guo, Sun‐Wei Guo
Fertility and sterility · 2007 · vol. 89(1) , pp. 246–250 · doi:10.1016/j.fertnstert.2006.11.009 · PMID:17239872 · W2076213656
article OA: bronze CC0 ⤵ 62 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This pilot study investigated the off-label use of valproic acid for adenomyosis and reported its findings.

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Abstract

Following on the heels of the discovery that endometriosis is an epigenetic disease, we conducted a pilot study on the off-label use of valproic acid to treat adenomyosis. We found that by the end of the 3-month treatment, all three recruited patients reported complete disappearance of dysmenorrhea, with an average of one-third reduction in uterus size.

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Condition tags

dysmenorrheaendometriosischronic_pelvic_painadenomyosis

MeSH descriptors

Analgesics Dysmenorrhea Endometriosis Enzyme Inhibitors Pelvic Pain Uterus Valproic Acid Administration, Oral Adult Analgesics Analgesics Drug Labeling Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (50)

Source provenance

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