Deep pelvic endometriosis: a radiologist’s guide to key imaging features with clinical and histopathologic review

review OA: closed CC0 ⤵ 21 in-corpus citations
AI-generated summary by claude@2026-06+body, 2026-06-07

Deep pelvic endometriosis, often mistaken for other pathologies, requires consideration in reproductive-age women with atypical pelvic symptoms, with MRI being crucial for accurate diagnosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text

The paper reviews imaging features and clinical/histopathologic considerations of deep pelvic endometriosis, focusing on how ultrasound and computed tomography can show nonspecific soft-tissue density masses that may be mistaken for infectious, inflammatory, or malignant causes in women of reproductive age presenting with gastrointestinal and urinary symptoms. It emphasizes that deep infiltrating disease can involve the gastrointestinal tract and urinary tract, producing findings such as bowel obstruction and hydronephrosis, and that further workup with magnetic resonance imaging is important for accurate diagnosis, treatment selection, and preoperative planning. A key caveat is that many presenting symptoms and standard imaging findings are nonspecific and therefore contribute to frequent diagnostic confusion with other pathologies. This paper is centrally about endometriosis — it provides a radiologist-focused guide to key imaging features and how these relate to clinical presentations and histopathology in deep pelvic endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 16,024 characters · extracted from oa-doi-fallback · 3 sections · click to expand

Abstract

While endometriosis typically affects the ovaries, deep infiltrating endometriosis can affect the gastrointestinal tract, urinary tract, and deep pelvis, awareness of which is important for radiologists. Symptoms are nonspecific and can range from chronic abdominal and deep pelvic pain to nausea, vomiting, diarrhea, constipation, hematuria, and rectal bleeding. Ultrasound and computed tomography may show nonspecific soft-tissue density masses causing bowel obstruction and hydronephrosis. This constellation of presenting symptoms and imaging evidence is easily mistaken for other pathologies including infectious gastroenteritis, diverticulitis, appendicitis, and malignancy, which may lead to unnecessary surgery or mismanagement. With this, deep pelvic endometriosis should be considered in the differential diagnosis in a female patient of reproductive age who presents with such atypical symptoms, and further work up with magnetic resonance imaging is imperative for accurate diagnosis, treatment selection, and preoperative planning. Similar content being viewed by others

References

Benagiano G, Brosens I (2006) History of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:449–463. doi:10.1016/j.bpobgyn.2006.01.007 Kratzer GL, Salvati EP (1955) Collective review of endometriosis of the colon. Am J Surg 90:866–869 Missmer SA, Hankinson SE, Spiegelman D, et al. (2004) Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol 160:784–796. doi:10.1093/aje/kwh275 Sangi-Haghpeykar H, Poindexter AN 3rd (1995) Epidemiology of endometriosis among parous women. Obstet Gynecol 85:983–992. doi:10.1016/0029-7844(95)00074-2 Giudice LC, Kao LC (2004) Endometriosis. Lancet 364:1789–1799. doi:10.1016/S0140-6736(04)17403-5 Cramer DW, Wilson E, Stillman RJ, et al. (1986) The relation of endometriosis to menstrual characteristics, smoking, and exercise. JAMA 255:1904–1908 Ballard K, Lane H, Hudelist G, Banerjee S, Wright J (2010) Can specific pain symptoms help in the diagnosis of endometriosis? A cohort study of women with chronic pelvic pain. Fertil Steril 94:20–27. doi:10.1016/j.fertnstert.2009.01.164 Sakamoto K, Maeda T, Yamamoto T, et al. (2006) Simultaneous laparoscopic treatment for rectosigmoid and ileal endometriosis. J Laparoendosc Adv Surg Tech A 16:251–255. doi:10.1089/lap.2006.16.251 Petta CA, Peloggia A (2015) Imaging techniques for the diagnosis of deep endometriosis. Austin J Reprod Med Infertil 2:1020 Moawad NS, Caplin A (2013) Diagnosis, management, and long-term outcomes of rectovaginal endometriosis. Int J Womens Health 5:753–763. doi:10.2147/IJWH.S37846 Slesser AA, Sultan S, Kubba F, Sellu DP (2010) Acute small bowel obstruction secondary to intestinal endometriosis, an elusive condition: a case report. World J Emerg Surg 5:27. doi:10.1186/1749-7922-5-27 Dmowski WP, Lesniewicz R, Rana N, Pepping P, Noursalehi M (1997) Changing trends in the diagnosis of endometriosis: a comparative study of women with pelvic endometriosis presenting with chronic pelvic pain or infertility. Fertil Steril 67:238–243. doi:10.1016/S0015-0282(97)81904-8 Seaman HE, Ballard KD, Wright JT, de Vries CS (2008) Endometriosis and its coexistence with irritable bowel syndrome and pelvic inflammatory disease: findings from a national case-control study—Part 2. BJOG 115:1392–1396. doi:10.1111/j.1471-0528.2008.01879.x Chapron C, Dubuisson JB, Pansini V, et al. (2002) Routine clinical examination is not sufficient for diagnosing and locating deeply infiltrating endometriosis. J Am Assoc Gynecol Laparosc 9:115–119 Hudelist G, Ballard K, English J, et al. (2011) Transvaginal sonography versus clinical examination in the preoperative diagnosis of deep infiltrating endometriosis. Ultrasound Obstet Gynecol 37:480–487. doi:10.1002/uog.8935 Denny E (2004) Women’s experience of endometriosis. J Adv Nurs 46:641–648. doi:10.1111/j.1365-2648.2004.03055.x Rogers PA, D’Hooghe TM, Fazleabas A, et al. (2013) Defining future directions for endometriosis research: workshop report from the 2011 World Congress of Endometriosis in Montpellier, France. Reprod Sci 20:483–499. doi:10.1177/1933719113477495 Kim JS, Hur H, Min BS, et al. (2009) Intestinal endometriosis mimicking carcinoma of rectum and sigmoid colon: a report of five cases. Yonsei Med J 50:732–735. doi:10.3349/ymj.2009.50.5.732 Yantiss RK, Clement PB, Young RH (2001) Endometriosis of the intestinal tract: a study of 44 cases of a disease that may cause diverse challenges in clinical and pathologic evaluation. Am J Surg Pathol 25:445–454 Remorgida V, Ferrero S, Fulcheri E, Ragni N, Martin DC (2007) Bowel endometriosis: presentation, diagnosis, and treatment. Obstet Gynecol Surv 62:461–470. doi:10.1097/01.ogx.0000268688.55653.5c Meyers WC, Kelvin FM, Jones RS (1979) Diagnosis and surgical treatment of colonic endometriosis. Arch Surg 114:169–175 Weed JC, Ray JE (1987) Endometriosis of the bowel. Obstet Gynecol 69:727–730 Collier HA, Gonzales LL, Bossert LJ (1962) Cyclic ascites as a manifestation of endometriosis. Report of a case. Obstet Gynecol 19:681–683 Macafee CH, Greer HL (1960) Intestinal endometriosis. A report of 29 cases and a survey of the literature. J Obstet Gynaecol Br Emp 67:539–555 Levitt MD, Hodby KJ, van Merwyk AJ, Glancy RJ (1989) Cyclical rectal bleeding in colorectal endometriosis. Aust N Z J Surg 59:941–943 Anaf V, El Nakadi I, Simon P, et al. (2004) Preferential infiltration of large bowel endometriosis along the nerves of the colon. Hum Reprod 19:996–1002. doi:10.1093/humrep/deh150 Remorgida V, Ragni N, Ferrero S, et al. (2005) The involvement of the interstitial Cajal cells and the enteric nervous system in bowel endometriosis. Hum Reprod 20:264–271. doi:10.1093/humrep/deh568 Collins DC (1955) A study of 50,000 specimens of the human vermiform appendix. Surg Gynecol Obstet 101:437–445 Khoo JJ, Ismail MS, Tiu CC (2004) Endometriosis of the appendix presenting as acute appendicitis. Singap Med J 45:435–436 Driman DK, Melega DE, Vilos GA, Plewes EA (2000) Mucocele of the appendix secondary to endometriosis. Report of two cases, one with localized pseudomyxoma peritonei. Am J Clin Pathol 113:860–864. doi:10.1309/EUTL-BC88-TLAX-1UJ4 Curbelo-Pena Y, Guedes-De la Puente X, Saladich-Cubero M, et al. (2015) Endometriosis causing acute appendicitis complicated with hemoperitoneum. J Surg Case Rep. doi:10.1093/jscr/rjv097 Collins DC (1951) Endometriosis of the vermiform appendix; review of literature, with addition of nine new instances, one of which caused severe melena. AMA Arch Surg 63:617–622 Muthyala T, Sikka P, Aggarwal N, et al. (2015) Endometriosis presenting as carcinoma colon in a perimenopausal woman. J Midlife Health 6:122–124. doi:10.4103/0976-7800.165592 Donnez J, Spada F, Squifflet J, Nisolle M (2000) Bladder endometriosis must be considered as bladder adenomyosis. Fertil Steril 74:1175–1181 Gabriel B, Nassif J, Trompoukis P, Barata S, Wattiez A (2011) Prevalence and management of urinary tract endometriosis: a clinical case series. Urology 78:1269–1274. doi:10.1016/j.urology.2011.07.1403 Tarumi Y, Mori T, Kusuki I, Ito F, Kitawaki J (2015) Endometrioid adenocarcinoma arising from deep infiltrating endometriosis involving the bladder: a case report and review of the literature. Gynecol Oncol Rep 13:68–70. doi:10.1016/j.gore.2015.07.003 Chamie LP, Blasbalg R, Pereira RM, Warmbrand G, Serafini PC (2011) Findings of pelvic endometriosis at transvaginal US, MR imaging, and laparoscopy. Radiographics 31:E77–100. doi:10.1148/rg.314105193 Schonman R, Dotan Z, Weintraub AY, et al. (2013) Deep endometriosis inflicting the bladder: long-term outcomes of surgical management. Arch Gynecol Obstet 288:1323–1328. doi:10.1007/s00404-013-2917-6 Leone Roberti Maggiore U, Ferrero S, Salvatore S (2015) Urinary incontinence and bladder endometriosis: conservative management. Int Urogynecol J 26:159–162. doi:10.1007/s00192-014-2487-6 Bogart LM, Berry SH, Clemens JQ (2007) Symptoms of interstitial cystitis, painful bladder syndrome and similar diseases in women: a systematic review. J Urol 177:450–456. doi:10.1016/j.juro.2006.09.032 Seracchioli R, Mabrouk M, Manuzzi L, et al. (2008) Importance of retroperitoneal ureteric evaluation in cases of deep infiltrating endometriosis. J Minim Invasive Gynecol 15:435–439. doi:10.1016/j.jmig.2008.03.005 Goncalves MO, Podgaec S, Dias JA Jr, Gonzalez M, Abrao MS (2010) Transvaginal ultrasonography with bowel preparation is able to predict the number of lesions and rectosigmoid layers affected in cases of deep endometriosis, defining surgical strategy. Hum Reprod 25:665–671. doi:10.1093/humrep/dep433 Bazot M, Darai E, Hourani R, et al. (2004) Deep pelvic endometriosis: MR imaging for diagnosis and prediction of extension of disease. Radiology 232:379–389. doi:10.1148/radiol.2322030762 Vimercati A, Achilarre MT, Scardapane A, et al. (2012) Accuracy of transvaginal sonography and contrast-enhanced magnetic resonance-colonography for the presurgical staging of deep infiltrating endometriosis. Ultrasound Obstet Gynecol 40:592–603. doi:10.1002/uog.11179 Hirai M, Shibata K, Sagai H, Sekiya S, Goldberg BB (1995) Transvaginal pulsed and color Doppler sonography for the evaluation of adenomyosis. J Ultrasound Med 14:529–532 Sakhel K, Abuhamad A (2012) Sonography of adenomyosis. J Ultrasound Med 31:805–808 Ferrero S, Biscaldi E, Vellone VG, Venturini PL, Leone Roberti Maggiore U (2016) Computed tomographic colonography versus rectal-water contrast transvaginal ultrasonography in the diagnosis of rectosigmoid endometriosis: a pilot study. Ultrasound Obstet Gynecol. doi:10.1002/uog.15905 Trippia CH, Zomer MT, Terazaki CR, et al. (2016) Relevance of imaging examinations in the surgical planning of patients with bowel endometriosis. Clin Med Insights Reprod Health 10:1–8. doi:10.4137/CMRH.S29472 Benacerraf BR, Groszmann Y, Hornstein MD, Bromley B (2015) Deep infiltrating endometriosis of the bowel wall: the comet sign. J Ultrasound Med 34:537–542. doi:10.7863/ultra.34.3.537 Guerriero S, Ajossa S, Gerada M, et al. (2008) Diagnostic value of transvaginal ‘tenderness-guided’ ultrasonography for the prediction of location of deep endometriosis. Hum Reprod 23:2452–2457. doi:10.1093/humrep/den293 Fratelli N, Scioscia M, Bassi E, et al. (2013) Transvaginal sonography for preoperative assessment of deep endometriosis. J Clin Ultrasound 41:69–75. doi:10.1002/jcu.22018 Fedele L, Bianchi S, Portuese A, Borruto F, Dorta M (1998) Transrectal ultrasonography in the assessment of rectovaginal endometriosis. Obstet Gynecol 91:444–448 Rossini LG, Ribeiro PA, Rodrigues FC, et al. (2012) Transrectal ultrasound—techniques and outcomes in the management of intestinal endometriosis. Endosc Ultrasound 1:23–35. doi:10.7178/eus.01.005 Griffiths A, Koutsouridou R, Vaughan S, et al. (2008) Transrectal ultrasound and the diagnosis of rectovaginal endometriosis: a prospective observational study. Acta Obstet Gynecol Scand 87:445–448. doi:10.1080/00016340801948318 Fedele L, Bianchi S, Raffaelli R, Portuese A (1997) Pre-operative assessment of bladder endometriosis. Hum Reprod 12:2519–2522 Pateman K, Holland TK, Knez J, et al. (2015) Should a detailed ultrasound examination of the complete urinary tract be routinely performed in women with suspected pelvic endometriosis? Hum Reprod 30:2802–2807. doi:10.1093/humrep/dev246 Savelli L, Manuzzi L, Pollastri P, et al. (2009) Diagnostic accuracy and potential limitations of transvaginal sonography for bladder endometriosis. Ultrasound Obstet Gynecol 34:595–600. doi:10.1002/uog.7356 Pateman K, Mavrelos D, Hoo WL, et al. (2013) Visualization of ureters on standard gynecological transvaginal scan: a feasibility study. Ultrasound Obstet Gynecol 41:696–701. doi:10.1002/uog.12468 Faccioli N, Foti G, Manfredi R, et al. (2010) Evaluation of colonic involvement in endometriosis: double-contrast barium enema versus magnetic resonance imaging. Abdom Imaging 35:414–421. doi:10.1007/s00261-009-9544-5 Roman H, Carilho J, Da Costa C, et al. (2016) Computed tomography-based virtual colonoscopy in the assessment of bowel endometriosis: the surgeon’s point of view. Gynecol Obstet Fertil 44:3–10. doi:10.1016/j.gyobfe.2015.11.008 Iosca S, Lumia D, Bracchi E, et al. (2013) Multislice computed tomography with colon water distension (MSCT-c) in the study of intestinal and ureteral endometriosis. Clin Imaging 37:1061–1068. doi:10.1016/j.clinimag.2013.07.003 Landi S, Barbieri F, Fiaccavento A, et al. (2004) Preoperative double-contrast barium enema in patients with suspected intestinal endometriosis. J Am Assoc Gynecol Laparosc 11:223–228 Faccioli N, Manfredi R, Mainardi P, et al. (2008) Barium enema evaluation of colonic involvement in endometriosis. AJR Am J Roentgenol 190:1050–1054. doi:10.2214/ajr.07.3062 Yoon JH, Choi D, Jang KT, et al. (2010) Deep rectosigmoid endometriosis: “mushroom cap” sign on T2-weighted MR imaging. Abdom Imaging 35:726–731. doi:10.1007/s00261-010-9643-3 Hottat N, Larrousse C, Anaf V, et al. (2009) Endometriosis: contribution of 3.0-T pelvic MR imaging in preoperative assessment—initial results. Radiology 253:126–134. doi:10.1148/radiol.2531082113 Menni K, Facchetti L, Cabassa P (2016) Extragenital endometriosis: assessment with MR imaging. A pictorial review. Br J Radiol 89:20150672. doi:10.1259/bjr.20150672 Coutinho A Jr, Bittencourt LK, Pires CE, et al. (2011) MR imaging in deep pelvic endometriosis: a pictorial essay. Radiographics 31:549–567. doi:10.1148/rg.312105144 Loubeyre P, Petignat P, Jacob S, et al. (2009) Anatomic distribution of posterior deeply infiltrating endometriosis on MRI after vaginal and rectal gel opacification. AJR Am J Roentgenol 192:1625–1631. doi:10.2214/AJR.08.1856 Kruger K, Behrendt K, Niedobitek-Kreuter G, Koltermann K, Ebert AD (2013) Location-dependent value of pelvic MRI in the preoperative diagnosis of endometriosis. Eur J Obstet Gynecol Reprod Biol 169:93–98. doi:10.1016/j.ejogrb.2013.02.007 Balleyguier C, Roupret M, Nguyen T, et al. (2004) Ureteral endometriosis: the role of magnetic resonance imaging. J Am Assoc Gynecol Laparosc 11:530–536 Corwin MT, Gerscovich EO, Lamba R, Wilson M, McGahan JP (2014) Differentiation of ovarian endometriomas from hemorrhagic cysts at MR imaging: utility of the T2 dark spot sign. Radiology 271:126–132. doi:10.1148/radiol.13131394 Siegelman ES, Oliver ER (2012) MR imaging of endometriosis: ten imaging pearls. Radiographics 32:1675–1691. doi:10.1148/rg.326125518 Kataoka ML, Togashi K, Yamaoka T, et al. (2005) Posterior cul-de-sac obliteration associated with endometriosis: MR imaging evaluation. Radiology 234:815–823. doi:10.1148/radiol.2343031366 Mussa FF, Younes Z, Tihan T, Lacy BE (2001) Anasarca and small bowel obstruction secondary to endometriosis. J Clin Gastroenterol 32:167–171

Acknowledgements

The authors acknowledge the assistance of Eric J. Gray and Sonia Watson, Ph.D., for editing the manuscript and Christopher M. Brown for illustration design. Author information Authors and Affiliations Corresponding author Ethics declarations Funding No funding was received for this study. Conflicts of interest The authors declare that they have no conflict of interest. Ethical approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent Statement of informed consent was not applicable since the manuscript does not contain any patient data. Rights and permissions About this article Cite this article Darvishzadeh, A., McEachern, W., Lee, T.K. et al. Deep pelvic endometriosis: a radiologist’s guide to key imaging features with clinical and histopathologic review. Abdom Radiol 41, 2380–2400 (2016). https://doi.org/10.1007/s00261-016-0956-8 Published: Issue date: DOI: https://doi.org/10.1007/s00261-016-0956-8

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Pelvis Pelvis Diagnosis, Differential Endometriosis Female Humans Pelvis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (75)

Cited by (21)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:20:43.714878+00:00
License: CC0 · commercial use OK